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Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study
BACKGROUND AND PURPOSE: Lithuania is one of the countries with the highest incidence of tick‐borne encephalitis (TBE) in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814845/ https://www.ncbi.nlm.nih.gov/pubmed/29053888 http://dx.doi.org/10.1111/ene.13486 |
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author | Radzišauskienė, D. Žagminas, K. Ašoklienė, L. Jasionis, A. Mameniškienė, R. Ambrozaitis, A. Jančorienė, L. Jatužis, D. Petraitytė, I. Mockienė, E. |
author_facet | Radzišauskienė, D. Žagminas, K. Ašoklienė, L. Jasionis, A. Mameniškienė, R. Ambrozaitis, A. Jančorienė, L. Jatužis, D. Petraitytė, I. Mockienė, E. |
author_sort | Radzišauskienė, D. |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Lithuania is one of the countries with the highest incidence of tick‐borne encephalitis (TBE) in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years. METHODS: Surveillance data available on the website of the Centre for Communicable Diseases and AIDS of Lithuania were used to describe the epidemiological patterns of TBE. The retrospective study included 712 patients hospitalized in the Centre for Infectious Diseases and the Centre for Neurology of Vilnius University in the years 2005–2014. RESULTS: Tick‐borne encephalitis incidence rates have been increasing by 8.5% per year for the 45‐year period from 1970 to 2014. The joinpoint model finds two joinpoints at 1991 and 1994, with a significant decrease of 8.4% per year (P < 0.05) prior to the joinpoint at 1991, and a rise of 195.2% afterwards. TBE presented with meningoencephalitis in 556 cases (81.3%). A total of 129 patients (18%) had a severe case of the disease. The most common neurological signs were ataxia (579, 81.3%), meningeal signs (474, 66.5%) and tremor (338, 47.5%). Limb paresis was observed in 6.3% of patients. Five patients (0.7%) died, and 544 patients (76.7%) were discharged with sequelae. CONCLUSIONS: Intensified efforts in promoting TBE vaccination will be needed in the light of the high incidence and expanded spatial distribution. Significant prognostic factors for severe cases of the disease were age above 61 and delayed immune response of specific immunoglobulin G. |
format | Online Article Text |
id | pubmed-5814845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58148452018-02-27 Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study Radzišauskienė, D. Žagminas, K. Ašoklienė, L. Jasionis, A. Mameniškienė, R. Ambrozaitis, A. Jančorienė, L. Jatužis, D. Petraitytė, I. Mockienė, E. Eur J Neurol Original Articles BACKGROUND AND PURPOSE: Lithuania is one of the countries with the highest incidence of tick‐borne encephalitis (TBE) in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years. METHODS: Surveillance data available on the website of the Centre for Communicable Diseases and AIDS of Lithuania were used to describe the epidemiological patterns of TBE. The retrospective study included 712 patients hospitalized in the Centre for Infectious Diseases and the Centre for Neurology of Vilnius University in the years 2005–2014. RESULTS: Tick‐borne encephalitis incidence rates have been increasing by 8.5% per year for the 45‐year period from 1970 to 2014. The joinpoint model finds two joinpoints at 1991 and 1994, with a significant decrease of 8.4% per year (P < 0.05) prior to the joinpoint at 1991, and a rise of 195.2% afterwards. TBE presented with meningoencephalitis in 556 cases (81.3%). A total of 129 patients (18%) had a severe case of the disease. The most common neurological signs were ataxia (579, 81.3%), meningeal signs (474, 66.5%) and tremor (338, 47.5%). Limb paresis was observed in 6.3% of patients. Five patients (0.7%) died, and 544 patients (76.7%) were discharged with sequelae. CONCLUSIONS: Intensified efforts in promoting TBE vaccination will be needed in the light of the high incidence and expanded spatial distribution. Significant prognostic factors for severe cases of the disease were age above 61 and delayed immune response of specific immunoglobulin G. John Wiley and Sons Inc. 2017-12-06 2018-02 /pmc/articles/PMC5814845/ /pubmed/29053888 http://dx.doi.org/10.1111/ene.13486 Text en © 2017 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Radzišauskienė, D. Žagminas, K. Ašoklienė, L. Jasionis, A. Mameniškienė, R. Ambrozaitis, A. Jančorienė, L. Jatužis, D. Petraitytė, I. Mockienė, E. Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
title | Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
title_full | Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
title_fullStr | Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
title_full_unstemmed | Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
title_short | Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
title_sort | epidemiological patterns of tick‐borne encephalitis in lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814845/ https://www.ncbi.nlm.nih.gov/pubmed/29053888 http://dx.doi.org/10.1111/ene.13486 |
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