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Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study

BACKGROUND: Helicobacter pylori is an important etiologic factor for peptic ulcers and gastric cancer, one of the top ten leading causes of cancer death in Puerto Rico. However, the prevalence of H. pylori infections in this population was previously unknown. The aim of this study was to examine the...

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Autores principales: González‐Pons, María, Soto‐Salgado, Marievelisse, Sevilla, Javier, Márquez‐Lespier, Juan M., Morgan, Douglas, Pérez, Cynthia M., Cruz‐Correa, Marcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814898/
https://www.ncbi.nlm.nih.gov/pubmed/29210527
http://dx.doi.org/10.1111/hel.12453
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author González‐Pons, María
Soto‐Salgado, Marievelisse
Sevilla, Javier
Márquez‐Lespier, Juan M.
Morgan, Douglas
Pérez, Cynthia M.
Cruz‐Correa, Marcia
author_facet González‐Pons, María
Soto‐Salgado, Marievelisse
Sevilla, Javier
Márquez‐Lespier, Juan M.
Morgan, Douglas
Pérez, Cynthia M.
Cruz‐Correa, Marcia
author_sort González‐Pons, María
collection PubMed
description BACKGROUND: Helicobacter pylori is an important etiologic factor for peptic ulcers and gastric cancer, one of the top ten leading causes of cancer death in Puerto Rico. However, the prevalence of H. pylori infections in this population was previously unknown. The aim of this study was to examine the seroprevalence of H. pylori and its associated risk factors in Puerto Rico. MATERIALS AND METHODS: A cross‐sectional study was designed using an existing population‐based biorepository. Seropositivity was determined using the Premier(™) H. pylori immunoassay. Helicobacter pylori seroprevalence was estimated with 95% confidence using marginal standardization following logistic regression. To assess the risk factors associated with H. pylori seropositivity, a multivariable log‐binomial model was fitted to estimate the prevalence ratio (PR) and its 95% confidence interval (95% CI). RESULTS: A total of 528 population‐based serum samples were analyzed. The mean age of the study population was 41 ± 12 years, of whom 55.3% were females. The overall seroprevalence of H. pylori was 33.0% (95% CI = 28.3%‐38.1%). Increasing age and having <12 years of education were significantly (P < .05) associated with H. pylori seropositivity in the multivariable model; however, residing in counties with low population density reached marginal significance (P = .085). CONCLUSIONS: We report that H. pylori infection is common among Hispanics living in Puerto Rico. The H. pylori seroprevalence observed in Puerto Rico is similar to the seroprevalence reported in the overall population of the United States. The association between H. pylori seroprevalence and the risk factors analyzed offers insight into the epidemiology of gastric cancer in Puerto Rico and warrants further investigation.
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spelling pubmed-58148982018-02-27 Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study González‐Pons, María Soto‐Salgado, Marievelisse Sevilla, Javier Márquez‐Lespier, Juan M. Morgan, Douglas Pérez, Cynthia M. Cruz‐Correa, Marcia Helicobacter Original Articles BACKGROUND: Helicobacter pylori is an important etiologic factor for peptic ulcers and gastric cancer, one of the top ten leading causes of cancer death in Puerto Rico. However, the prevalence of H. pylori infections in this population was previously unknown. The aim of this study was to examine the seroprevalence of H. pylori and its associated risk factors in Puerto Rico. MATERIALS AND METHODS: A cross‐sectional study was designed using an existing population‐based biorepository. Seropositivity was determined using the Premier(™) H. pylori immunoassay. Helicobacter pylori seroprevalence was estimated with 95% confidence using marginal standardization following logistic regression. To assess the risk factors associated with H. pylori seropositivity, a multivariable log‐binomial model was fitted to estimate the prevalence ratio (PR) and its 95% confidence interval (95% CI). RESULTS: A total of 528 population‐based serum samples were analyzed. The mean age of the study population was 41 ± 12 years, of whom 55.3% were females. The overall seroprevalence of H. pylori was 33.0% (95% CI = 28.3%‐38.1%). Increasing age and having <12 years of education were significantly (P < .05) associated with H. pylori seropositivity in the multivariable model; however, residing in counties with low population density reached marginal significance (P = .085). CONCLUSIONS: We report that H. pylori infection is common among Hispanics living in Puerto Rico. The H. pylori seroprevalence observed in Puerto Rico is similar to the seroprevalence reported in the overall population of the United States. The association between H. pylori seroprevalence and the risk factors analyzed offers insight into the epidemiology of gastric cancer in Puerto Rico and warrants further investigation. John Wiley and Sons Inc. 2017-12-06 2018-02 /pmc/articles/PMC5814898/ /pubmed/29210527 http://dx.doi.org/10.1111/hel.12453 Text en © 2017 The Authors. Helicobacter Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
González‐Pons, María
Soto‐Salgado, Marievelisse
Sevilla, Javier
Márquez‐Lespier, Juan M.
Morgan, Douglas
Pérez, Cynthia M.
Cruz‐Correa, Marcia
Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study
title Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study
title_full Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study
title_fullStr Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study
title_full_unstemmed Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study
title_short Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population‐based study
title_sort seroprevalence of helicobacter pylori in hispanics living in puerto rico: a population‐based study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814898/
https://www.ncbi.nlm.nih.gov/pubmed/29210527
http://dx.doi.org/10.1111/hel.12453
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