Cargando…

Brief Report: A Phase IIb Trial of a Novel Extended‐Release Microsphere Formulation of Triamcinolone Acetonide for Intraarticular Injection in Knee Osteoarthritis

OBJECTIVE: FX006 is a novel, microsphere‐based, extended‐release formulation of triamcinolone acetonide for intraarticular (IA) injection designed to maintain treatment concentration in the joint and provide prolonged analgesic benefits in patients with osteoarthritis (OA) of the knee. This study wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conaghan, Philip G., Cohen, Stanley B., Berenbaum, Francis, Lufkin, Joelle, Johnson, James R., Bodick, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Osteoarthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814922/ https://www.ncbi.nlm.nih.gov/pubmed/29088579 http://dx.doi.org/10.1002/art.40364

Ejemplares similares

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study
por: Conaghan, Philip G., et al.
Publicado: (2018)

Triamcinolone acetonide extended-release in patients with osteoarthritis and type 2 diabetes: a randomized, phase 2 study
por: Russell, Steven J, et al.
Publicado: (2018)

Machine-learning, MRI bone shape and important clinical outcomes in osteoarthritis: data from the Osteoarthritis Initiative
por: Bowes, Michael A., et al.
Publicado: (2021)

A randomized, phase IIa study to assess the systemic exposure of triamcinolone acetonide following injection of extended-release triamcinolone acetonide or traditional triamcinolone acetonide into both knees of patients with bilateral knee osteoarthritis
por: Kivitz, Alan, et al.
Publicado: (2019)

Efficacy of Triamcinolone Acetonide Extended-Release in Participants with Unilateral Knee Osteoarthritis: A Post Hoc Analysis
por: Langworthy, Michael J., et al.
Publicado: (2019)

Randomized, Double‐Blind, Placebo‐Controlled Trial of Intraarticular Trans‐Capsaicin for Pain Associated With Osteoarthritis of the Knee
por: Stevens, Randall M., et al.
Publicado: (2019)

Safety and Systemic Exposure of Triamcinolone Acetonide Following Ultrasound-Guided Intra-Articular Injection of Triamcinolone Extended-Release or Standard Triamcinolone Acetonide in Patients with Shoulder Osteoarthritis: An Open-Label, Randomized Study
por: Hanson, Peter, et al.
Publicado: (2021)

Rescue Analgesic Medication Use by Patients Treated with Triamcinolone Acetonide Extended-Release for Knee Osteoarthritis Pain: Pooled Analysis of Three Phase 2/3 Randomized Clinical Trials
por: Kivitz, Alan J., et al.
Publicado: (2019)

Brief Report: Intraarticular Sprifermin Not Only Increases Cartilage Thickness, but Also Reduces Cartilage Loss: Location‐Independent Post Hoc Analysis Using Magnetic Resonance Imaging
por: Eckstein, Felix, et al.
Publicado: (2015)

Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis
por: Louati, Karine, et al.
Publicado: (2015)

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis
por: Berthelot, Jean-Marie, et al.
Publicado: (2019)

Association between osteoarthritis and dyslipidaemia: a systematic literature review and meta-analysis
por: Baudart, Pauline, et al.
Publicado: (2017)

The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial
por: Dakin, Paula, et al.
Publicado: (2019)

Use of machine learning in osteoarthritis research: a systematic literature review
por: Binvignat, Marie, et al.
Publicado: (2022)

Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis
por: Campbell, T. Mark, et al.
Publicado: (2016)

Lorecivivint, a Novel Intraarticular CDC‐like Kinase 2 and Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial
por: Yazici, Yusuf, et al.
Publicado: (2020)

Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study
por: Courties, Alice, et al.
Publicado: (2017)

Development of classification criteria for hand osteoarthritis: comparative analyses of persons with and without hand osteoarthritis
por: Haugen, Ida K, et al.
Publicado: (2020)

Cardiometabolic risk factors in primary centred and rotator cuff-related shoulder osteoarthritis: a comparative study
por: Juge, Pierre-Antoine, et al.
Publicado: (2017)

Pain in hand osteoarthritis is associated with crystals in the synovial fluid: a cross-sectional study of people with hand osteoarthritis undergoing surgery
por: Døssing, Anna, et al.
Publicado: (2023)

Pollutants: a candidate as a new risk factor for osteoarthritis—results from a systematic literature review
por: Deprouw, Camille, et al.
Publicado: (2022)

A Randomized, Open-Label, Single-Dose Study to Assess Safety and Systemic Exposure of Triamcinolone Acetonide Extended-Release in Patients With Hip Osteoarthritis
por: Kivitz, Alan, et al.
Publicado: (2022)

General Safety and Tolerability of Subcutaneous Tanezumab for Osteoarthritis: A Pooled Analysis of Three Randomized, Placebo‐Controlled Trials
por: Berenbaum, Francis, et al.
Publicado: (2022)

Translation of clinical problems in osteoarthritis into pathophysiological research goals
por: van der Kraan, Peter M, et al.
Publicado: (2016)

Patient-reported outcome measures in osteoarthritis: a systematic search and review of their use and psychometric properties
por: Lundgren-Nilsson, Åsa, et al.
Publicado: (2018)

Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping
por: van Helvoort, Eefje Martine, et al.
Publicado: (2021)

Defining an International Standard Set of Outcome Measures for Patients With Hip or Knee Osteoarthritis: Consensus of the International Consortium for Health Outcomes Measurement Hip and Knee Osteoarthritis Working Group
por: Rolfson, Ola, et al.
Publicado: (2016)

Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study
por: Eckstein, Felix, et al.
Publicado: (2021)

Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period
por: Berenbaum, Francis, et al.
Publicado: (2020)

Safety and Efficacy of Repeat Administration of Triamcinolone Acetonide Extended-release in Osteoarthritis of the Knee: A Phase 3b, Open-label Study
por: Spitzer, Andrew I., et al.
Publicado: (2019)

Triamcinolone Acetonide Extended-Release: A Review in Osteoarthritis Pain of the Knee
por: Paik, Julia, et al.
Publicado: (2019)

Improved Treatment Effect of Triamcinolone Acetonide Extended-Release in Patients with Concordant Baseline Pain Scores on the Average Daily Pain and Western Ontario and McMaster Universities Osteoarthritis Index Pain Scales
por: Ross, Edgar, et al.
Publicado: (2021)

Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2)
por: Haugen, Ida K, et al.
Publicado: (2022)

Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study
por: Zhu, Yanqiu, et al.
Publicado: (2023)

Magnetic Resonance Imaging–Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis
por: Macri, Erin M., et al.
Publicado: (2022)

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis
por: Kloppenburg, Margreet, et al.
Publicado: (2019)

Comparison of efficacy between triamcinolone acetonide and triamcinolone hexacetonide for intraarticular therapy in juvenile idiopathic arthritis: a retrospective analysis
por: Chun, Angela, et al.
Publicado: (2022)

Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
por: Camacho-Encina, María, et al.
Publicado: (2019)

Average symptom trajectories following incident radiographic knee osteoarthritis: data from the Osteoarthritis Initiative
por: Whittle, Rebecca, et al.
Publicado: (2016)

Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study
por: Wei, Jie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4k1k3fjs2l0jnakaev8e07q3sq