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FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

Common Chromosomal Fragile Sites (CFSs) are specific genomic regions prone to form breaks on metaphase chromosomes in response to replication stress. Moreover, CFSs are mutational hotspots in cancer genomes, showing that the mutational mechanisms that operate at CFSs are highly active in cancer cell...

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Detalles Bibliográficos
Autores principales:	Pentzold, Constanze, Shah, Shiraz Ali, Hansen, Niels Richard, Le Tallec, Benoît, Seguin-Orlando, Andaine, Debatisse, Michelle, Lisby, Michael, Oestergaard, Vibe H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815096/ https://www.ncbi.nlm.nih.gov/pubmed/29253234 http://dx.doi.org/10.1093/nar/gkx1260

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