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Prespacer processing and specific integration in a Type I-A CRISPR system

The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. Adaptation is dependent on the Cas1 and Cas2 proteins along with varying accessory proteins. Here we analyse the process in Sulfolobus solfataricus, showing that while C...

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Detalles Bibliográficos
Autores principales:	Rollie, Clare, Graham, Shirley, Rouillon, Christophe, White, Malcolm F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	NAR Breakthrough Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815122/ https://www.ncbi.nlm.nih.gov/pubmed/29228332 http://dx.doi.org/10.1093/nar/gkx1232

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