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Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex

Rad4/XPC recognizes diverse DNA lesions including ultraviolet-photolesions and carcinogen-DNA adducts, initiating nucleotide excision repair. Studies have suggested that Rad4/XPC senses lesion-induced helix-destabilization to flip out nucleotides from damaged DNA sites. However, characterizing how D...

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Detalles Bibliográficos
Autores principales:	Chakraborty, Sagnik, Steinbach, Peter J, Paul, Debamita, Mu, Hong, Broyde, Suse, Min, Jung-Hyun, Ansari, Anjum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815138/ https://www.ncbi.nlm.nih.gov/pubmed/29267981 http://dx.doi.org/10.1093/nar/gkx1216

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