Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelination. Microglia play a pivotal role in regulating myelinat...

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Detalles Bibliográficos
Autores principales: Beckmann, Nicolau, Giorgetti, Elisa, Neuhaus, Anna, Zurbruegg, Stefan, Accart, Nathalie, Smith, Paul, Perdoux, Julien, Perrot, Ludovic, Nash, Mark, Desrayaud, Sandrine, Wipfli, Peter, Frieauff, Wilfried, Shimshek, Derya R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815182/
https://www.ncbi.nlm.nih.gov/pubmed/29448957
http://dx.doi.org/10.1186/s40478-018-0510-8

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