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New therapeutic strategies to treat human cancers expressing mutant p53 proteins
The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis. The TP53 is the most frequently inactivated gene in human cancers. This leads to the production of mutant p53 proteins...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815234/ https://www.ncbi.nlm.nih.gov/pubmed/29448954 http://dx.doi.org/10.1186/s13046-018-0705-7 |