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New therapeutic strategies to treat human cancers expressing mutant p53 proteins

The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis. The TP53 is the most frequently inactivated gene in human cancers. This leads to the production of mutant p53 proteins...

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Detalles Bibliográficos
Autores principales: Blandino, Giovanni, Di Agostino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815234/
https://www.ncbi.nlm.nih.gov/pubmed/29448954
http://dx.doi.org/10.1186/s13046-018-0705-7

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