Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is a highly prevalent neurodegenerative disorder characterized by pathological hallmarks of beta-amyloid plaque deposits, tau pathology, inflammation, and cognitive decline. Treatment remains a clinical obstacle due to lack of effective therapeutics. Agonists tar...

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Detalles Bibliográficos
Autores principales: Casali, Brad T., Reed-Geaghan, Erin G., Landreth, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815248/
https://www.ncbi.nlm.nih.gov/pubmed/29448961
http://dx.doi.org/10.1186/s12974-018-1091-y

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