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Retrosplenial Cortex Indexes Stability beyond the Spatial Domain

Retrosplenial cortex (RSC) is highly responsive to landmarks in the environment that remain fixed in a permanent location, and this has been linked with its known involvement in scene and spatial processing. However, it is unclear whether RSC representations of permanence are a purely spatial phenom...

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Autores principales: Auger, Stephen D., Maguire, Eleanor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815348/
https://www.ncbi.nlm.nih.gov/pubmed/29311139
http://dx.doi.org/10.1523/JNEUROSCI.2602-17.2017
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author Auger, Stephen D.
Maguire, Eleanor A.
author_facet Auger, Stephen D.
Maguire, Eleanor A.
author_sort Auger, Stephen D.
collection PubMed
description Retrosplenial cortex (RSC) is highly responsive to landmarks in the environment that remain fixed in a permanent location, and this has been linked with its known involvement in scene and spatial processing. However, it is unclear whether RSC representations of permanence are a purely spatial phenomenon or whether they extend into behavioral and conceptual domains. To test this, during functional MRI scanning, we had people (males and females) read three different types of sentences that described either something permanent or transient. The first two sentence types were imageable, with a focus either on a spatial landmark or on an action. The third type of sentence involved non-imageable abstract concepts. We found that, in addition to being more active for sentences describing landmarks with a permanent location in space, RSC was also significantly engaged by sentences describing stable and consistent behaviors or actions, as long as they were rooted within a concrete imageable setting. RSC was not responsive to abstract concepts, even those that embodied the notion of stability. Similarly, it was not engaged by imageable sentences with transient contents. In contrast, parahippocampal cortex was more engaged by imageable sentences describing landmarks, whereas the hippocampus was active for all imageable sentences. In addition, for imageable sentences describing permanence, there was bidirectional functional coupling between RSC and these medial temporal lobe structures. It appears, therefore, that RSC-mediated permanence representations could be helpful for more than spatially mapping environments and may also provide information about the reliability of events occurring within them. SIGNIFICANCE STATEMENT The retrosplenial cortex (RSC) is known to process information about landmarks in the environment that have a fixed, permanent location. Here we tested whether this permanence response was apparent beyond the spatial domain, which could have implications for understanding the role of the RSC more widely across cognition. We found that the RSC was engaged not only by permanent landmarks but also by stable and consistent actions. It was not responsive to transient landmarks or actions or to abstract concepts, even those that embodied the notion of stability. We conclude that the RSC might do more than help to map spatial environments, by possibly also providing information about the reliability of events occurring within them.
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spelling pubmed-58153482018-02-28 Retrosplenial Cortex Indexes Stability beyond the Spatial Domain Auger, Stephen D. Maguire, Eleanor A. J Neurosci Research Articles Retrosplenial cortex (RSC) is highly responsive to landmarks in the environment that remain fixed in a permanent location, and this has been linked with its known involvement in scene and spatial processing. However, it is unclear whether RSC representations of permanence are a purely spatial phenomenon or whether they extend into behavioral and conceptual domains. To test this, during functional MRI scanning, we had people (males and females) read three different types of sentences that described either something permanent or transient. The first two sentence types were imageable, with a focus either on a spatial landmark or on an action. The third type of sentence involved non-imageable abstract concepts. We found that, in addition to being more active for sentences describing landmarks with a permanent location in space, RSC was also significantly engaged by sentences describing stable and consistent behaviors or actions, as long as they were rooted within a concrete imageable setting. RSC was not responsive to abstract concepts, even those that embodied the notion of stability. Similarly, it was not engaged by imageable sentences with transient contents. In contrast, parahippocampal cortex was more engaged by imageable sentences describing landmarks, whereas the hippocampus was active for all imageable sentences. In addition, for imageable sentences describing permanence, there was bidirectional functional coupling between RSC and these medial temporal lobe structures. It appears, therefore, that RSC-mediated permanence representations could be helpful for more than spatially mapping environments and may also provide information about the reliability of events occurring within them. SIGNIFICANCE STATEMENT The retrosplenial cortex (RSC) is known to process information about landmarks in the environment that have a fixed, permanent location. Here we tested whether this permanence response was apparent beyond the spatial domain, which could have implications for understanding the role of the RSC more widely across cognition. We found that the RSC was engaged not only by permanent landmarks but also by stable and consistent actions. It was not responsive to transient landmarks or actions or to abstract concepts, even those that embodied the notion of stability. We conclude that the RSC might do more than help to map spatial environments, by possibly also providing information about the reliability of events occurring within them. Society for Neuroscience 2018-02-07 /pmc/articles/PMC5815348/ /pubmed/29311139 http://dx.doi.org/10.1523/JNEUROSCI.2602-17.2017 Text en Copyright © 2018 Auger et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Articles
Auger, Stephen D.
Maguire, Eleanor A.
Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
title Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
title_full Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
title_fullStr Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
title_full_unstemmed Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
title_short Retrosplenial Cortex Indexes Stability beyond the Spatial Domain
title_sort retrosplenial cortex indexes stability beyond the spatial domain
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815348/
https://www.ncbi.nlm.nih.gov/pubmed/29311139
http://dx.doi.org/10.1523/JNEUROSCI.2602-17.2017
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