Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer

We have demonstrated that assessments of microRNA (miRNA) expressions in circulating peripheral blood mononucleated cell (PBMC) and sputum specimens, respectively, may help diagnose lung cancer. To assess the individual and combined analysis of the miRNAs across the different body fluids for lung ca...

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Autores principales: Su, Jian, Leng, Qixin, Lin, Yanli, Ma, Jie, Jiang, Fangran, Lee, Cheng-Ju, Fang, HongBin, Jiang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815414/
https://www.ncbi.nlm.nih.gov/pubmed/29467585
http://dx.doi.org/10.1177/1179299X18759297
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author Su, Jian
Leng, Qixin
Lin, Yanli
Ma, Jie
Jiang, Fangran
Lee, Cheng-Ju
Fang, HongBin
Jiang, Feng
author_facet Su, Jian
Leng, Qixin
Lin, Yanli
Ma, Jie
Jiang, Fangran
Lee, Cheng-Ju
Fang, HongBin
Jiang, Feng
author_sort Su, Jian
collection PubMed
description We have demonstrated that assessments of microRNA (miRNA) expressions in circulating peripheral blood mononucleated cell (PBMC) and sputum specimens, respectively, may help diagnose lung cancer. To assess the individual and combined analysis of the miRNAs across the different body fluids for lung cancer early detection, we analyse a panel of 3 sputum miRNAs (miRs-21, 31, and 210) and a panel of 2 PBMC miRNAs (miRs-19b-3p and 29b-3p) in a discovery cohort of 68 patients with lung cancer and 66 cancer-free smokers. We find that integrating 2 sputum miRNAs (miRs-31 and 210) and 1 PBMC miRNA (miR-19b-3p) has higher sensitivity (86.8%) and specificity (92.4%) compared with the individual panels. The synergistic value of the integrated panel of 3 biomarkers is confirmed in a validation cohort, independent of stage and histological type of lung cancer, and patients’ age, sex, and ethnicity. Integrating circulating immunological and sputum biomarkers could improve the early detection of lung cancer.
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spelling pubmed-58154142018-02-21 Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer Su, Jian Leng, Qixin Lin, Yanli Ma, Jie Jiang, Fangran Lee, Cheng-Ju Fang, HongBin Jiang, Feng Biomark Cancer Original Research We have demonstrated that assessments of microRNA (miRNA) expressions in circulating peripheral blood mononucleated cell (PBMC) and sputum specimens, respectively, may help diagnose lung cancer. To assess the individual and combined analysis of the miRNAs across the different body fluids for lung cancer early detection, we analyse a panel of 3 sputum miRNAs (miRs-21, 31, and 210) and a panel of 2 PBMC miRNAs (miRs-19b-3p and 29b-3p) in a discovery cohort of 68 patients with lung cancer and 66 cancer-free smokers. We find that integrating 2 sputum miRNAs (miRs-31 and 210) and 1 PBMC miRNA (miR-19b-3p) has higher sensitivity (86.8%) and specificity (92.4%) compared with the individual panels. The synergistic value of the integrated panel of 3 biomarkers is confirmed in a validation cohort, independent of stage and histological type of lung cancer, and patients’ age, sex, and ethnicity. Integrating circulating immunological and sputum biomarkers could improve the early detection of lung cancer. SAGE Publications 2018-02-13 /pmc/articles/PMC5815414/ /pubmed/29467585 http://dx.doi.org/10.1177/1179299X18759297 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Su, Jian
Leng, Qixin
Lin, Yanli
Ma, Jie
Jiang, Fangran
Lee, Cheng-Ju
Fang, HongBin
Jiang, Feng
Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer
title Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer
title_full Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer
title_fullStr Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer
title_full_unstemmed Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer
title_short Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer
title_sort integrating circulating immunological and sputum biomarkers for the early detection of lung cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815414/
https://www.ncbi.nlm.nih.gov/pubmed/29467585
http://dx.doi.org/10.1177/1179299X18759297
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