Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis

PURPOSE: The compound heterozygous mutations in the β subunit of chaperonin containing TCP-1 (CCT), encoded by CCT2, lead to the Leber congenital amaurosis (LCA). In this study, a cct2 mutant line of zebrafish was established to investigate the role of CCT2 mutations in LCA in vertebrates. METHODS:...

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Detalles Bibliográficos
Autores principales: Minegishi, Yuriko, Nakaya, Naoki, Tomarev, Stanislav I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815422/
https://www.ncbi.nlm.nih.gov/pubmed/29450543
http://dx.doi.org/10.1167/iovs.17-22919

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