Cargando…

Calcium signalling links MYC to NUAK1

NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability. As such, NUAK1 may play key roles in multiple diseases ranging from neurodegener...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monteverde, T, Tait-Mulder, J, Hedley, A, Knight, J R, Sansom, O J, Murphy, D J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815498/ https://www.ncbi.nlm.nih.gov/pubmed/29106388 http://dx.doi.org/10.1038/onc.2017.394

Ejemplares similares

NUAK1 and NUAK2 Fine-Tune TGF-β Signaling
por: van de Vis, Reinofke A. J., et al.
Publicado: (2021)

NUAK1 links genomic instability and senescence
por: Bernard, David, et al.
Publicado: (2010)

NUAK2: an emerging acral melanoma oncogene
por: Namiki, Takeshi, et al.
Publicado: (2011)

NUAK Kinases: Brain–Ovary Axis
por: Molina, Ester, et al.
Publicado: (2021)

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
por: Cossa, Giacomo, et al.
Publicado: (2020)

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription
por: Cossa, Giacomo, et al.
Publicado: (2021)

Muscle-specific Knock-out of NUAK Family SNF1-like Kinase 1 (NUAK1) Prevents High Fat Diet-induced Glucose Intolerance
por: Inazuka, Fumika, et al.
Publicado: (2012)

Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
por: Liu, Yuhan, et al.
Publicado: (2023)

NUAK1 (ARK5) Is Associated with Poor Prognosis in Ovarian Cancer
por: Phippen, Neil T., et al.
Publicado: (2016)

NUAK2 is a critical YAP target in liver cancer
por: Yuan, Wei-Chien, et al.
Publicado: (2018)

Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover
por: Brooks, David, et al.
Publicado: (2020)

Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
por: Courchet, Virginie, et al.
Publicado: (2018)

MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1
por: Shi, L, et al.
Publicado: (2014)

Gene expression profiling of NUAK kinase overexpression in Drosophila larval muscle development
por: Brooks, David, et al.
Publicado: (2022)

MYC‐y mice: From tumour initiation to therapeutic targeting of endogenous MYC
por: Morton, Jennifer P., et al.
Publicado: (2013)

Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer
por: Buensuceso, Adrian, et al.
Publicado: (2022)

LINC00958 Promotes The Malignancy Of Nasopharyngeal Carcinoma By Sponging microRNA-625 And Thus Upregulating NUAK1
por: Chen, Meijuan, et al.
Publicado: (2019)

NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β‐dependent regulation of PLK4
por: Whyte, Declan, et al.
Publicado: (2023)

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
por: Banerjee, Sourav, et al.
Publicado: (2013)

A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling
por: Bonnard, Carine, et al.
Publicado: (2020)

Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
por: Habib, Tania, et al.
Publicado: (2007)

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling
por: Oh, Seunghee, et al.
Publicado: (2020)

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Cytosolic NUAK1 Enhances ATP Production by Maintaining Proper Glycolysis and Mitochondrial Function in Cancer Cells
por: Escalona, Emilia, et al.
Publicado: (2020)

miR-622 Counteracts the NUAK1-Induced Gastric Cancer Cell Proliferation and the Antioxidative Stress
por: Yang, Jian, et al.
Publicado: (2022)

NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma
por: Yang, Huiru, et al.
Publicado: (2023)

NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network
por: Mammarella, Eleonora, et al.
Publicado: (2021)

A Novel Role for NUAK1 in Promoting Ovarian Cancer Metastasis through Regulation of Fibronectin Production in Spheroids
por: Fritz, Jamie Lee, et al.
Publicado: (2020)

Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities
por: Chen, Yiran, et al.
Publicado: (2020)

Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin
por: Yang, Changshun, et al.
Publicado: (2021)

LncRNA NEAT1/miR-204/NUAK1 Axis is a Potential Therapeutic Target for Non-Small Cell Lung Cancer
por: Zhao, Ming-Ming, et al.
Publicado: (2020)

LINC00958 Promotes the Malignancy of Nasopharyngeal Carcinoma by Sponging microRNA-625 and Thus Upregulating NUAK1 [Retraction]
Publicado: (2023)

Correction for: Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin
por: Yang, Changshun, et al.
Publicado: (2021)

microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer
por: Obayashi, Mariko, et al.
Publicado: (2016)

Calcium-dependent binding of Myc to calmodulin
por: Raffeiner, Philipp, et al.
Publicado: (2016)

High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching
por: Blazejewski, Sara M., et al.
Publicado: (2021)

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2
por: Lin, Ritian, et al.
Publicado: (2022)

LncRNA SNHG1 functions as a ceRNA to antagonize the effect of miR‐145a‐5p on the down‐regulation of NUAK1 in nasopharyngeal carcinoma cell
por: Lan, Xintang, et al.
Publicado: (2018)

The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells
por: Singh, Tanu, et al.
Publicado: (2022)

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo
por: Phesse, T J, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6tnujp44nkflnksjm0atig3tul