Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr(17) phosphorylation, and exacerbated ischaemia-reperfusion injury

AIMS: PKN1 is a stress-responsive protein kinase acting downstream of small GTP-binding proteins of the Rho/Rac family. The aim was to determine its role in endogenous cardioprotection. METHODS AND RESULTS: Hearts from PKN1 knockout (KO) or wild type (WT) littermate control mice were perfused in Lan...

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Detalles Bibliográficos
Autores principales: Francois, Asvi A, Obasanjo-Blackshire, Kofo, Clark, James E, Boguslavskyi, Andrii, Holt, Mark R, Parker, Peter J, Marber, Michael S, Heads, Richard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815577/
https://www.ncbi.nlm.nih.gov/pubmed/29045568
http://dx.doi.org/10.1093/cvr/cvx206

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