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Cas9-mediated excision of proximal DNaseI/H3K4me3 signatures confers robust silencing of microRNA and long non-coding RNA genes
CRISPR/Cas9-based approaches have greatly facilitated targeted genomic deletions. Contrary to coding genes however, which can be functionally knocked out by frame-shift mutagenesis, non-coding RNA (ncRNA) gene knockouts have remained challenging. Here we present a universal ncRNA knockout approach g...
Autores principales: | Janga, Harshavardhan, Aznaourova, Marina, Boldt, Fabian, Damm, Katrin, Grünweller, Arnold, Schulte, Leon N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815609/ https://www.ncbi.nlm.nih.gov/pubmed/29451908 http://dx.doi.org/10.1371/journal.pone.0193066 |
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