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Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection
Human immunodeficiency virus type 1 (HIV) infection substantially increases the risk of developing tuberculosis. There is extensive depletion of Mycobacterium tuberculosis–specific CD4(+) T cells in blood during early HIV infection, but little is known about responses in the lungs at this stage. Giv...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815627/ https://www.ncbi.nlm.nih.gov/pubmed/29029171 http://dx.doi.org/10.1093/infdis/jix529 |
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author | Bunjun, Rubina Riou, Catherine Soares, Andreia P Thawer, Narjis Müller, Tracey L Kiravu, Agano Ginbot, Zekarias Oni, Tolu Goliath, Rene Kalsdorf, Barbara von Groote-Bidlingmaier, Florian Hanekom, Willem Walzl, Gerhard Wilkinson, Robert J Burgers, Wendy A |
author_facet | Bunjun, Rubina Riou, Catherine Soares, Andreia P Thawer, Narjis Müller, Tracey L Kiravu, Agano Ginbot, Zekarias Oni, Tolu Goliath, Rene Kalsdorf, Barbara von Groote-Bidlingmaier, Florian Hanekom, Willem Walzl, Gerhard Wilkinson, Robert J Burgers, Wendy A |
author_sort | Bunjun, Rubina |
collection | PubMed |
description | Human immunodeficiency virus type 1 (HIV) infection substantially increases the risk of developing tuberculosis. There is extensive depletion of Mycobacterium tuberculosis–specific CD4(+) T cells in blood during early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4(+) T-cell destruction, we investigated M. tuberculosis–specific responses in bronchoalveolar lavage (BAL) from persons with latent M. tuberculosis infection and untreated HIV coinfection with preserved CD4(+) T-cell counts. M. tuberculosis–specific CD4(+) T-cell cytokine (interferon γ, tumor necrosis factor α, and interleukin 2) responses were discordant in frequency and function between BAL and blood. Responses in BAL were 15-fold lower in HIV-infected persons as compared to uninfected persons (P = .048), whereas blood responses were 2-fold lower (P = .006). However, an increase in T cells in the airways in HIV-infected persons resulted in the overall number of M. tuberculosis–specific CD4(+) T cells in BAL being similar. Our study highlights the important insights gained from studying M. tuberculosis immunity at the site of disease during HIV infection. |
format | Online Article Text |
id | pubmed-5815627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58156272018-02-23 Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection Bunjun, Rubina Riou, Catherine Soares, Andreia P Thawer, Narjis Müller, Tracey L Kiravu, Agano Ginbot, Zekarias Oni, Tolu Goliath, Rene Kalsdorf, Barbara von Groote-Bidlingmaier, Florian Hanekom, Willem Walzl, Gerhard Wilkinson, Robert J Burgers, Wendy A J Infect Dis Major Articles and Brief Reports Human immunodeficiency virus type 1 (HIV) infection substantially increases the risk of developing tuberculosis. There is extensive depletion of Mycobacterium tuberculosis–specific CD4(+) T cells in blood during early HIV infection, but little is known about responses in the lungs at this stage. Given that mucosal organs are a principal target for HIV-mediated CD4(+) T-cell destruction, we investigated M. tuberculosis–specific responses in bronchoalveolar lavage (BAL) from persons with latent M. tuberculosis infection and untreated HIV coinfection with preserved CD4(+) T-cell counts. M. tuberculosis–specific CD4(+) T-cell cytokine (interferon γ, tumor necrosis factor α, and interleukin 2) responses were discordant in frequency and function between BAL and blood. Responses in BAL were 15-fold lower in HIV-infected persons as compared to uninfected persons (P = .048), whereas blood responses were 2-fold lower (P = .006). However, an increase in T cells in the airways in HIV-infected persons resulted in the overall number of M. tuberculosis–specific CD4(+) T cells in BAL being similar. Our study highlights the important insights gained from studying M. tuberculosis immunity at the site of disease during HIV infection. Oxford University Press 2017-12-19 2017-10-05 /pmc/articles/PMC5815627/ /pubmed/29029171 http://dx.doi.org/10.1093/infdis/jix529 Text en © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Major Articles and Brief Reports Bunjun, Rubina Riou, Catherine Soares, Andreia P Thawer, Narjis Müller, Tracey L Kiravu, Agano Ginbot, Zekarias Oni, Tolu Goliath, Rene Kalsdorf, Barbara von Groote-Bidlingmaier, Florian Hanekom, Willem Walzl, Gerhard Wilkinson, Robert J Burgers, Wendy A Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection |
title | Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection |
title_full | Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection |
title_fullStr | Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection |
title_full_unstemmed | Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection |
title_short | Effect of HIV on the Frequency and Number of Mycobacterium tuberculosis–Specific CD4(+) T Cells in Blood and Airways During Latent M. tuberculosis Infection |
title_sort | effect of hiv on the frequency and number of mycobacterium tuberculosis–specific cd4(+) t cells in blood and airways during latent m. tuberculosis infection |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815627/ https://www.ncbi.nlm.nih.gov/pubmed/29029171 http://dx.doi.org/10.1093/infdis/jix529 |
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