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Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports

RATIONALE: This article is aimed to retrospect the clinicopathological data of 2 cases of gastric MANENCs. MANEC is a rare biphasic tumor type that is coexistence of dual neuroendocrine and adenocarcinoma differentiation with each composing exceeding 30% volume. Gastric MANEC have just been reported...

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Autores principales: Tang, Qiang, Zhou, Zili, Chen, Jinhuang, Di, Maojun, Ji, Jintong, Yuan, Wenzheng, Liu, Zhengyi, Wu, Liang, Zhang, Xudan, Li, Kang, Shu, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815743/
https://www.ncbi.nlm.nih.gov/pubmed/29390331
http://dx.doi.org/10.1097/MD.0000000000009189
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author Tang, Qiang
Zhou, Zili
Chen, Jinhuang
Di, Maojun
Ji, Jintong
Yuan, Wenzheng
Liu, Zhengyi
Wu, Liang
Zhang, Xudan
Li, Kang
Shu, Xiaogang
author_facet Tang, Qiang
Zhou, Zili
Chen, Jinhuang
Di, Maojun
Ji, Jintong
Yuan, Wenzheng
Liu, Zhengyi
Wu, Liang
Zhang, Xudan
Li, Kang
Shu, Xiaogang
author_sort Tang, Qiang
collection PubMed
description RATIONALE: This article is aimed to retrospect the clinicopathological data of 2 cases of gastric MANENCs. MANEC is a rare biphasic tumor type that is coexistence of dual neuroendocrine and adenocarcinoma differentiation with each composing exceeding 30% volume. Gastric MANEC have just been reported anecdotally in the literature due to their rarity and heterogeneity. According to our study, these neoplasms have 3 different metastasis patterns: only adenocarcinomatous or neuroendocrine carcinoma and both of the 2 components. We first focus on the correlation of metastasis characteristics with prognosis in gastric MANEC, which may be potential implications for the choice of chemotherapy. PATIENT CONCERNS: The 2 cases of patient shared several symptoms: epigastric discomfort, weight loss, hematemesis, or melena. DIAGNOSIS: The 2 patients were diagnosis as MANEC based on the identification of histopathological analysis. In case 1, the poor differentiated adenocarcinoma accounted for 30%, the neuroendocrine part account for 70% and both of the 2 components metastasized to the lymph nodes, whereas in case 2, poorly differentiated adenocarcinoma accounted for 70%, the neuroendocrine part for 30% and only the glandular component invaded regional lymph nodes. INTERVENTIONS: The first patient underwent laparoscopic radical gastrectomy and underwent adjuvant chemotherapy, combination of cisplatin, and etoposide successfully. The second patient received radical gastronomy, and did not receive any chemotherapy due to general weakness. OUTCOMES: The first patient is alive with no evidence of recurrence, and the second patient died 6 months after the operation. LESSONS: The assessment of metastatic sites should be a routine pathological practice, which is crucial for clinical decision-making and the selection of management.
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spelling pubmed-58157432018-02-28 Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports Tang, Qiang Zhou, Zili Chen, Jinhuang Di, Maojun Ji, Jintong Yuan, Wenzheng Liu, Zhengyi Wu, Liang Zhang, Xudan Li, Kang Shu, Xiaogang Medicine (Baltimore) 4500 RATIONALE: This article is aimed to retrospect the clinicopathological data of 2 cases of gastric MANENCs. MANEC is a rare biphasic tumor type that is coexistence of dual neuroendocrine and adenocarcinoma differentiation with each composing exceeding 30% volume. Gastric MANEC have just been reported anecdotally in the literature due to their rarity and heterogeneity. According to our study, these neoplasms have 3 different metastasis patterns: only adenocarcinomatous or neuroendocrine carcinoma and both of the 2 components. We first focus on the correlation of metastasis characteristics with prognosis in gastric MANEC, which may be potential implications for the choice of chemotherapy. PATIENT CONCERNS: The 2 cases of patient shared several symptoms: epigastric discomfort, weight loss, hematemesis, or melena. DIAGNOSIS: The 2 patients were diagnosis as MANEC based on the identification of histopathological analysis. In case 1, the poor differentiated adenocarcinoma accounted for 30%, the neuroendocrine part account for 70% and both of the 2 components metastasized to the lymph nodes, whereas in case 2, poorly differentiated adenocarcinoma accounted for 70%, the neuroendocrine part for 30% and only the glandular component invaded regional lymph nodes. INTERVENTIONS: The first patient underwent laparoscopic radical gastrectomy and underwent adjuvant chemotherapy, combination of cisplatin, and etoposide successfully. The second patient received radical gastronomy, and did not receive any chemotherapy due to general weakness. OUTCOMES: The first patient is alive with no evidence of recurrence, and the second patient died 6 months after the operation. LESSONS: The assessment of metastatic sites should be a routine pathological practice, which is crucial for clinical decision-making and the selection of management. Wolters Kluwer Health 2017-12-15 /pmc/articles/PMC5815743/ /pubmed/29390331 http://dx.doi.org/10.1097/MD.0000000000009189 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-sa/4.0 This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0
spellingShingle 4500
Tang, Qiang
Zhou, Zili
Chen, Jinhuang
Di, Maojun
Ji, Jintong
Yuan, Wenzheng
Liu, Zhengyi
Wu, Liang
Zhang, Xudan
Li, Kang
Shu, Xiaogang
Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports
title Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports
title_full Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports
title_fullStr Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports
title_full_unstemmed Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports
title_short Correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: Two case reports
title_sort correlation of metastasis characteristics with prognosis in gastric mixed adenoneuroendocrine carcinoma: two case reports
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815743/
https://www.ncbi.nlm.nih.gov/pubmed/29390331
http://dx.doi.org/10.1097/MD.0000000000009189
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