Cargando…
Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report
RATIONALE: It is often challenging to discriminate between intrahepatic cholangiocarcinoma (ICC) and metastatic liver tumors, especially when the hepatic tumor is small and of a mass-forming type. PATIENT CONCERNS: We report a 69-year-old woman presented at our hospital with a small solid tumor in t...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815760/ https://www.ncbi.nlm.nih.gov/pubmed/29390348 http://dx.doi.org/10.1097/MD.0000000000009217 |
_version_ | 1783300563432112128 |
---|---|
author | Eso, Yuji Uza, Norimitsu Yamagishi, Hiroko Imada, Kazuaki Kimura, Yuto Masui, Toshihiko Kodama, Yuzo Seno, Hiroshi |
author_facet | Eso, Yuji Uza, Norimitsu Yamagishi, Hiroko Imada, Kazuaki Kimura, Yuto Masui, Toshihiko Kodama, Yuzo Seno, Hiroshi |
author_sort | Eso, Yuji |
collection | PubMed |
description | RATIONALE: It is often challenging to discriminate between intrahepatic cholangiocarcinoma (ICC) and metastatic liver tumors, especially when the hepatic tumor is small and of a mass-forming type. PATIENT CONCERNS: We report a 69-year-old woman presented at our hospital with a small solid tumor in the head of the pancreas that was previously discovered during a medical checkup. DIAGNOSES: The patient was diagnosed with synchronous pancreatic cancer and ICC. INTERVENTIONS: The patient underwent clinical, histological, immunohistological, and KRAS mutational analysis. OUTCOMES: Computed tomography revealed poorly enhanced small nodules in both the pancreatic head and liver. Biopsies of both nodules revealed adenocarcinoma; however, it was unclear whether the hepatic lesion was a metastasis of the pancreatic tumor or primary ICC. KRAS mutational analysis from FFPE biopsy samples revealed a discordance of mutation status between the tumors. Therefore, the patient was diagnosed with synchronous pancreatic cancer and ICC, whereupon she underwent hepatopancreatoduodenectomy. LESSONS: KRAS mutational analysis of FFPE biopsy samples can be utilized for differentiating between ICC and metastatic liver tumor. |
format | Online Article Text |
id | pubmed-5815760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-58157602018-02-28 Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report Eso, Yuji Uza, Norimitsu Yamagishi, Hiroko Imada, Kazuaki Kimura, Yuto Masui, Toshihiko Kodama, Yuzo Seno, Hiroshi Medicine (Baltimore) 4500 RATIONALE: It is often challenging to discriminate between intrahepatic cholangiocarcinoma (ICC) and metastatic liver tumors, especially when the hepatic tumor is small and of a mass-forming type. PATIENT CONCERNS: We report a 69-year-old woman presented at our hospital with a small solid tumor in the head of the pancreas that was previously discovered during a medical checkup. DIAGNOSES: The patient was diagnosed with synchronous pancreatic cancer and ICC. INTERVENTIONS: The patient underwent clinical, histological, immunohistological, and KRAS mutational analysis. OUTCOMES: Computed tomography revealed poorly enhanced small nodules in both the pancreatic head and liver. Biopsies of both nodules revealed adenocarcinoma; however, it was unclear whether the hepatic lesion was a metastasis of the pancreatic tumor or primary ICC. KRAS mutational analysis from FFPE biopsy samples revealed a discordance of mutation status between the tumors. Therefore, the patient was diagnosed with synchronous pancreatic cancer and ICC, whereupon she underwent hepatopancreatoduodenectomy. LESSONS: KRAS mutational analysis of FFPE biopsy samples can be utilized for differentiating between ICC and metastatic liver tumor. Wolters Kluwer Health 2017-12-15 /pmc/articles/PMC5815760/ /pubmed/29390348 http://dx.doi.org/10.1097/MD.0000000000009217 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4500 Eso, Yuji Uza, Norimitsu Yamagishi, Hiroko Imada, Kazuaki Kimura, Yuto Masui, Toshihiko Kodama, Yuzo Seno, Hiroshi Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report |
title | Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report |
title_full | Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report |
title_fullStr | Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report |
title_full_unstemmed | Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report |
title_short | Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: A case report |
title_sort | utility of kras mutational analysis in the preoperative diagnosis of synchronous pancreatic cancer and intrahepatic cholangiocarcinoma: a case report |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815760/ https://www.ncbi.nlm.nih.gov/pubmed/29390348 http://dx.doi.org/10.1097/MD.0000000000009217 |
work_keys_str_mv | AT esoyuji utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT uzanorimitsu utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT yamagishihiroko utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT imadakazuaki utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT kimurayuto utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT masuitoshihiko utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT kodamayuzo utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport AT senohiroshi utilityofkrasmutationalanalysisinthepreoperativediagnosisofsynchronouspancreaticcancerandintrahepaticcholangiocarcinomaacasereport |