TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We previously found that DNA demethylation on p53-deficient background leads to transcription of repetitive heterochromatin elements, followed...

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Detalles Bibliográficos
Autores principales: Leonova, Katerina, Safina, Alfiya, Nesher, Elimelech, Sandlesh, Poorva, Pratt, Rachel, Burkhart, Catherine, Lipchick, Brittany, Gitlin, Ilya, Frangou, Costakis, Koman, Igor, Wang, Jianmin, Kirsanov, Kirill, Yakubovskaya, Marianna G, Gudkov, Andrei V, Gurova, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815852/
https://www.ncbi.nlm.nih.gov/pubmed/29400649
http://dx.doi.org/10.7554/eLife.30842

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