Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

RIOK1 has recently been shown to play important roles in cancers, but its posttranslational regulation is largely unknown. Here we report that RIOK1 is methylated at K411 by SETD7 methyltransferase and that lysine-specific demethylase 1 (LSD1) reverses its methylation. The mutated RIOK1 (K411R) that...

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Detalles Bibliográficos
Autores principales: Hong, Xuehui, Huang, He, Qiu, Xingfeng, Ding, Zhijie, Feng, Xing, Zhu, Yuekun, Zhuo, Huiqin, Hou, Jingjing, Zhao, Jiabao, Cai, Wangyu, Sha, Ruihua, Hong, Xinya, Li, Yongxiang, Song, Hongjiang, Zhang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815853/
https://www.ncbi.nlm.nih.gov/pubmed/29384474
http://dx.doi.org/10.7554/eLife.29511

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