Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression

Sigma σ(1) and σ(2) receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and reward areas. While the drug also affec...

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Detalles Bibliográficos
Autores principales: Aguinaga, David, Medrano, Mireia, Vega-Quiroga, Ignacio, Gysling, Katia, Canela, Enric I., Navarro, Gemma, Franco, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816031/
https://www.ncbi.nlm.nih.gov/pubmed/29483862
http://dx.doi.org/10.3389/fnmol.2018.00017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816031/
https://www.ncbi.nlm.nih.gov/pubmed/29483862
http://dx.doi.org/10.3389/fnmol.2018.00017

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