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A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

The over-activation of NMDA receptor via the excessive glutamate is believed to one of the most causal factors associated with Alzheimer’s disease (AD), a progressive neurodegenerative brain disorder. Molecules that could protect against glutamate-induced neurotoxicity may hold therapeutic values fo...

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Detalles Bibliográficos
Autores principales:	Hu, Shengquan, Hu, Huihui, Mak, Shinghung, Cui, Guozhen, Lee, Mingyuen, Shan, Luchen, Wang, Yuqiang, Lin, Huangquan, Zhang, Zaijun, Han, Yifan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816056/ https://www.ncbi.nlm.nih.gov/pubmed/29483871 http://dx.doi.org/10.3389/fphar.2018.00073

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