Insight into the reaction mechanism of lipoyl synthase: a QM/MM study

Lipoyl synthase (LipA) catalyses the final step of the biosynthesis of the lipoyl cofactor by insertion of two sulfur atoms at the C6 and C8 atoms of the protein-bound octanoyl substrate. In this reaction, two [4Fe4S] clusters and two molecules of S-adenosyl-l-methionine are used. One of the two FeS...

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Detalles Bibliográficos
Autores principales: Dong, Geng, Cao, Lili, Ryde, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816104/
https://www.ncbi.nlm.nih.gov/pubmed/29204715
http://dx.doi.org/10.1007/s00775-017-1522-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816104/
https://www.ncbi.nlm.nih.gov/pubmed/29204715
http://dx.doi.org/10.1007/s00775-017-1522-8

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