Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

We have identified a phenomenon occurring in the usage of proposed “specific” Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation...

Descripción completa

Detalles Bibliográficos
Autores principales: Meurer, Steffen K., Weiskirchen, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816342/
https://www.ncbi.nlm.nih.gov/pubmed/29483873
http://dx.doi.org/10.3389/fphar.2018.00098
_version_ 1783300653331775488
author Meurer, Steffen K.
Weiskirchen, Ralf
author_facet Meurer, Steffen K.
Weiskirchen, Ralf
author_sort Meurer, Steffen K.
collection PubMed
description We have identified a phenomenon occurring in the usage of proposed “specific” Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation of all former studies using MAPK inhibitors.
format Online
Article
Text
id pubmed-5816342
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-58163422018-02-26 Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition! Meurer, Steffen K. Weiskirchen, Ralf Front Pharmacol Pharmacology We have identified a phenomenon occurring in the usage of proposed “specific” Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation of all former studies using MAPK inhibitors. Frontiers Media S.A. 2018-02-12 /pmc/articles/PMC5816342/ /pubmed/29483873 http://dx.doi.org/10.3389/fphar.2018.00098 Text en Copyright © 2018 Meurer and Weiskirchen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Meurer, Steffen K.
Weiskirchen, Ralf
Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
title Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
title_full Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
title_fullStr Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
title_full_unstemmed Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
title_short Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
title_sort usage of mitogen-activated protein kinase small molecule inhibitors: more than just inhibition!
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816342/
https://www.ncbi.nlm.nih.gov/pubmed/29483873
http://dx.doi.org/10.3389/fphar.2018.00098
work_keys_str_mv AT meurersteffenk usageofmitogenactivatedproteinkinasesmallmoleculeinhibitorsmorethanjustinhibition
AT weiskirchenralf usageofmitogenactivatedproteinkinasesmallmoleculeinhibitorsmorethanjustinhibition

Ejemplares similares