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Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during...

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Autores principales: Winder, Aaron T., Echagarruga, Christina, Zhang, Qingguang, Drew, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816345/
https://www.ncbi.nlm.nih.gov/pubmed/29184204
http://dx.doi.org/10.1038/s41593-017-0007-y
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author Winder, Aaron T.
Echagarruga, Christina
Zhang, Qingguang
Drew, Patrick J.
author_facet Winder, Aaron T.
Echagarruga, Christina
Zhang, Qingguang
Drew, Patrick J.
author_sort Winder, Aaron T.
collection PubMed
description Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest, and during whisker stimulation and volitional whisking. Here we show that neurovascular coupling was similar across states, and large spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input was blocked, and during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.
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spelling pubmed-58163452018-05-06 Weak correlations between hemodynamic signals and ongoing neural activity during the resting state Winder, Aaron T. Echagarruga, Christina Zhang, Qingguang Drew, Patrick J. Nat Neurosci Article Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest, and during whisker stimulation and volitional whisking. Here we show that neurovascular coupling was similar across states, and large spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input was blocked, and during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes. 2017-11-06 2017-12 /pmc/articles/PMC5816345/ /pubmed/29184204 http://dx.doi.org/10.1038/s41593-017-0007-y Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Winder, Aaron T.
Echagarruga, Christina
Zhang, Qingguang
Drew, Patrick J.
Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
title Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
title_full Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
title_fullStr Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
title_full_unstemmed Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
title_short Weak correlations between hemodynamic signals and ongoing neural activity during the resting state
title_sort weak correlations between hemodynamic signals and ongoing neural activity during the resting state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816345/
https://www.ncbi.nlm.nih.gov/pubmed/29184204
http://dx.doi.org/10.1038/s41593-017-0007-y
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