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Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters
BACKGROUND: Genome sequencing revealed that Streptomyces sp. can dedicate up to ~ 10% of their genomes for the biosynthesis of bioactive secondary metabolites. However, the majority of these biosynthetic gene clusters are only weakly expressed or not at all. Indeed, the biosynthesis of natural produ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816538/ https://www.ncbi.nlm.nih.gov/pubmed/29454348 http://dx.doi.org/10.1186/s12934-018-0874-2 |