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Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters

BACKGROUND: Genome sequencing revealed that Streptomyces sp. can dedicate up to ~ 10% of their genomes for the biosynthesis of bioactive secondary metabolites. However, the majority of these biosynthetic gene clusters are only weakly expressed or not at all. Indeed, the biosynthesis of natural produ...

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Detalles Bibliográficos
Autores principales:	Kallifidas, Dimitris, Jiang, Guangde, Ding, Yousong, Luesch, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816538/ https://www.ncbi.nlm.nih.gov/pubmed/29454348 http://dx.doi.org/10.1186/s12934-018-0874-2

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