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Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin

There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H(2)O(2) on corrosion of Ti6A...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Addison, Owen, Yu, Fei, Troconis, Brendy C. Rincon, Scully, John R., Davenport, Alison J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816596/
https://www.ncbi.nlm.nih.gov/pubmed/29453366
http://dx.doi.org/10.1038/s41598-018-21332-x
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author Zhang, Yue
Addison, Owen
Yu, Fei
Troconis, Brendy C. Rincon
Scully, John R.
Davenport, Alison J.
author_facet Zhang, Yue
Addison, Owen
Yu, Fei
Troconis, Brendy C. Rincon
Scully, John R.
Davenport, Alison J.
author_sort Zhang, Yue
collection PubMed
description There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H(2)O(2) on corrosion of Ti6Al4V in physiological saline is studied with electrochemical methods. It is found that albumin induces a time-dependent dissolution of Ti6Al4V in the presence of H(2)O(2) in physiology saline. Potentiostatic polarisation measurements show that albumin supresses dissolution in the presence of H(2)O(2) at short times (<24 h) but over longer time periods (120 h) it significantly accelerates corrosion, which is attributed to albumin-catalysed dissolution of the corrosion product layer resulting in formation of a thinner oxide film. Dissolution of Ti6Al4V in the presence of albumin and H(2)O(2) in physiological saline is also found to be dependent on potential: the titanium ion release rate is found to be higher (0.57 µg/cm(2)) at a lower potential (90 mV), where the oxide capacitance and resistance inferred from Electrochemical Impedance Spectroscopy also suggests a less resistant oxide film. The study highlights the importance of using more realistic solutions, and considering behaviour over longer time periods when testing corrosion resistance of metallic biomaterials.
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spelling pubmed-58165962018-02-21 Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin Zhang, Yue Addison, Owen Yu, Fei Troconis, Brendy C. Rincon Scully, John R. Davenport, Alison J. Sci Rep Article There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H(2)O(2) on corrosion of Ti6Al4V in physiological saline is studied with electrochemical methods. It is found that albumin induces a time-dependent dissolution of Ti6Al4V in the presence of H(2)O(2) in physiology saline. Potentiostatic polarisation measurements show that albumin supresses dissolution in the presence of H(2)O(2) at short times (<24 h) but over longer time periods (120 h) it significantly accelerates corrosion, which is attributed to albumin-catalysed dissolution of the corrosion product layer resulting in formation of a thinner oxide film. Dissolution of Ti6Al4V in the presence of albumin and H(2)O(2) in physiological saline is also found to be dependent on potential: the titanium ion release rate is found to be higher (0.57 µg/cm(2)) at a lower potential (90 mV), where the oxide capacitance and resistance inferred from Electrochemical Impedance Spectroscopy also suggests a less resistant oxide film. The study highlights the importance of using more realistic solutions, and considering behaviour over longer time periods when testing corrosion resistance of metallic biomaterials. Nature Publishing Group UK 2018-02-16 /pmc/articles/PMC5816596/ /pubmed/29453366 http://dx.doi.org/10.1038/s41598-018-21332-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Yue
Addison, Owen
Yu, Fei
Troconis, Brendy C. Rincon
Scully, John R.
Davenport, Alison J.
Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
title Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
title_full Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
title_fullStr Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
title_full_unstemmed Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
title_short Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
title_sort time-dependent enhanced corrosion of ti6al4v in the presence of h(2)o(2) and albumin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816596/
https://www.ncbi.nlm.nih.gov/pubmed/29453366
http://dx.doi.org/10.1038/s41598-018-21332-x
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