Cargando…
Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin
There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H(2)O(2) on corrosion of Ti6A...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816596/ https://www.ncbi.nlm.nih.gov/pubmed/29453366 http://dx.doi.org/10.1038/s41598-018-21332-x |
_version_ | 1783300711747944448 |
---|---|
author | Zhang, Yue Addison, Owen Yu, Fei Troconis, Brendy C. Rincon Scully, John R. Davenport, Alison J. |
author_facet | Zhang, Yue Addison, Owen Yu, Fei Troconis, Brendy C. Rincon Scully, John R. Davenport, Alison J. |
author_sort | Zhang, Yue |
collection | PubMed |
description | There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H(2)O(2) on corrosion of Ti6Al4V in physiological saline is studied with electrochemical methods. It is found that albumin induces a time-dependent dissolution of Ti6Al4V in the presence of H(2)O(2) in physiology saline. Potentiostatic polarisation measurements show that albumin supresses dissolution in the presence of H(2)O(2) at short times (<24 h) but over longer time periods (120 h) it significantly accelerates corrosion, which is attributed to albumin-catalysed dissolution of the corrosion product layer resulting in formation of a thinner oxide film. Dissolution of Ti6Al4V in the presence of albumin and H(2)O(2) in physiological saline is also found to be dependent on potential: the titanium ion release rate is found to be higher (0.57 µg/cm(2)) at a lower potential (90 mV), where the oxide capacitance and resistance inferred from Electrochemical Impedance Spectroscopy also suggests a less resistant oxide film. The study highlights the importance of using more realistic solutions, and considering behaviour over longer time periods when testing corrosion resistance of metallic biomaterials. |
format | Online Article Text |
id | pubmed-5816596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58165962018-02-21 Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin Zhang, Yue Addison, Owen Yu, Fei Troconis, Brendy C. Rincon Scully, John R. Davenport, Alison J. Sci Rep Article There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H(2)O(2) on corrosion of Ti6Al4V in physiological saline is studied with electrochemical methods. It is found that albumin induces a time-dependent dissolution of Ti6Al4V in the presence of H(2)O(2) in physiology saline. Potentiostatic polarisation measurements show that albumin supresses dissolution in the presence of H(2)O(2) at short times (<24 h) but over longer time periods (120 h) it significantly accelerates corrosion, which is attributed to albumin-catalysed dissolution of the corrosion product layer resulting in formation of a thinner oxide film. Dissolution of Ti6Al4V in the presence of albumin and H(2)O(2) in physiological saline is also found to be dependent on potential: the titanium ion release rate is found to be higher (0.57 µg/cm(2)) at a lower potential (90 mV), where the oxide capacitance and resistance inferred from Electrochemical Impedance Spectroscopy also suggests a less resistant oxide film. The study highlights the importance of using more realistic solutions, and considering behaviour over longer time periods when testing corrosion resistance of metallic biomaterials. Nature Publishing Group UK 2018-02-16 /pmc/articles/PMC5816596/ /pubmed/29453366 http://dx.doi.org/10.1038/s41598-018-21332-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Yue Addison, Owen Yu, Fei Troconis, Brendy C. Rincon Scully, John R. Davenport, Alison J. Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin |
title | Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin |
title_full | Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin |
title_fullStr | Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin |
title_full_unstemmed | Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin |
title_short | Time-dependent Enhanced Corrosion of Ti6Al4V in the Presence of H(2)O(2) and Albumin |
title_sort | time-dependent enhanced corrosion of ti6al4v in the presence of h(2)o(2) and albumin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816596/ https://www.ncbi.nlm.nih.gov/pubmed/29453366 http://dx.doi.org/10.1038/s41598-018-21332-x |
work_keys_str_mv | AT zhangyue timedependentenhancedcorrosionofti6al4vinthepresenceofh2o2andalbumin AT addisonowen timedependentenhancedcorrosionofti6al4vinthepresenceofh2o2andalbumin AT yufei timedependentenhancedcorrosionofti6al4vinthepresenceofh2o2andalbumin AT troconisbrendycrincon timedependentenhancedcorrosionofti6al4vinthepresenceofh2o2andalbumin AT scullyjohnr timedependentenhancedcorrosionofti6al4vinthepresenceofh2o2andalbumin AT davenportalisonj timedependentenhancedcorrosionofti6al4vinthepresenceofh2o2andalbumin |