PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry

The synthesis of middle-to-late-replicating DNA can be affected independently of the rest of the genome by down-regulating the tumor suppressor PREP1 (PKNOX1). Indeed, DNA combing shows that PREP1 down-regulation affects DNA replication rate, increases the number of simultaneously firing origins and...

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Detalles Bibliográficos
Autores principales: Palmigiano, Angela, Santaniello, Francesco, Cerutti, Aurora, Penkov, Dmitry, Purushothaman, Divya, Makhija, Ekta, Luzi, Lucilla, di Fagagna, Fabrizio d’Adda, Pelicci, Pier Giuseppe, Shivashankar, Viveswara, Dellino, Gaetano Ivan, Blasi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816642/
https://www.ncbi.nlm.nih.gov/pubmed/29453404
http://dx.doi.org/10.1038/s41598-018-21363-4

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