Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection

Baseline resistance-associated substitutions (RASs) have variable impacts in clinical trials but their prevalence and impact in real-world patients remains unclear. We performed baseline resistance testing using a commercial assay (10% cutoff) for 486 patients treated with LDV/SOF or SMV/SOF, with o...

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Detalles Bibliográficos
Autores principales: Wang, Gary P., Terrault, Norah, Reeves, Jacqueline D., Liu, Lin, Li, Eric, Zhao, Lisa, Lim, Joseph K., Morelli, Giuseppe, Kuo, Alexander, Levitsky, Josh, Sherman, Kenneth E., Frazier, Lynn M., Ramani, Ananthakrishnan, Peter, Joy, Akuskevich, Lucy, Fried, Michael W., Nelson, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816647/
https://www.ncbi.nlm.nih.gov/pubmed/29453451
http://dx.doi.org/10.1038/s41598-018-21303-2

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