Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations

The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that distinguish benign from malignant polyps remain unclear. To molecularly characterize polyps, we utilized Cancer Adjacent Polyp (CAP) and Cancer Free Polyp (CFP) patients. CAPs had t...

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Detalles Bibliográficos
Autores principales: Druliner, Brooke R., Wang, Panwen, Bae, Taejeong, Baheti, Saurabh, Slettedahl, Seth, Mahoney, Douglas, Vasmatzis, Nikolaos, Xu, Hang, Kim, Minsoo, Bockol, Matthew, O’Brien, Daniel, Grill, Diane, Warner, Nathaniel, Munoz-Gomez, Miguel, Kossick, Kimberlee, Johnson, Ruth, Mouchli, Mohamad, Felmlee-Devine, Donna, Washechek-Aletto, Jill, Smyrk, Thomas, Oberg, Ann, Wang, Junwen, Chia, Nicholas, Abyzov, Alexej, Ahlquist, David, Boardman, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816667/
https://www.ncbi.nlm.nih.gov/pubmed/29453410
http://dx.doi.org/10.1038/s41598-018-21525-4

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