Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the oxidative decarboxylation of isocitrate in the citric acid cycle. In the α(2)βγ heterotetramer of NAD-IDH, the γ subunit plays the regulatory role and the β subunit the structural role. Previous biochemical data have shown that mam...

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Detalles Bibliográficos
Autores principales: Liu, Yabing, Hu, Lejia, Ma, Tengfei, Yang, Jun, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816668/
https://www.ncbi.nlm.nih.gov/pubmed/29453450
http://dx.doi.org/10.1038/s41598-018-21584-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816668/
https://www.ncbi.nlm.nih.gov/pubmed/29453450
http://dx.doi.org/10.1038/s41598-018-21584-7

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