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The where, what, and when of membrane protein degradation in neurons
Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816708/ https://www.ncbi.nlm.nih.gov/pubmed/28884504 http://dx.doi.org/10.1002/dneu.22534 |
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author | Jin, Eugene Jennifer Kiral, Ferdi Ridvan Hiesinger, Peter Robin |
author_facet | Jin, Eugene Jennifer Kiral, Ferdi Ridvan Hiesinger, Peter Robin |
author_sort | Jin, Eugene Jennifer |
collection | PubMed |
description | Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo‐specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons. © 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 283–297, 2018 |
format | Online Article Text |
id | pubmed-5816708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58167082018-03-12 The where, what, and when of membrane protein degradation in neurons Jin, Eugene Jennifer Kiral, Ferdi Ridvan Hiesinger, Peter Robin Dev Neurobiol Review Articles Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo‐specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons. © 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 283–297, 2018 John Wiley and Sons Inc. 2017-09-19 2018-03 /pmc/articles/PMC5816708/ /pubmed/28884504 http://dx.doi.org/10.1002/dneu.22534 Text en © 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Jin, Eugene Jennifer Kiral, Ferdi Ridvan Hiesinger, Peter Robin The where, what, and when of membrane protein degradation in neurons |
title | The where, what, and when of membrane protein degradation in neurons |
title_full | The where, what, and when of membrane protein degradation in neurons |
title_fullStr | The where, what, and when of membrane protein degradation in neurons |
title_full_unstemmed | The where, what, and when of membrane protein degradation in neurons |
title_short | The where, what, and when of membrane protein degradation in neurons |
title_sort | where, what, and when of membrane protein degradation in neurons |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816708/ https://www.ncbi.nlm.nih.gov/pubmed/28884504 http://dx.doi.org/10.1002/dneu.22534 |
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