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The where, what, and when of membrane protein degradation in neurons

Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent c...

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Detalles Bibliográficos
Autores principales: Jin, Eugene Jennifer, Kiral, Ferdi Ridvan, Hiesinger, Peter Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816708/
https://www.ncbi.nlm.nih.gov/pubmed/28884504
http://dx.doi.org/10.1002/dneu.22534
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author Jin, Eugene Jennifer
Kiral, Ferdi Ridvan
Hiesinger, Peter Robin
author_facet Jin, Eugene Jennifer
Kiral, Ferdi Ridvan
Hiesinger, Peter Robin
author_sort Jin, Eugene Jennifer
collection PubMed
description Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo‐specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons. © 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 283–297, 2018
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spelling pubmed-58167082018-03-12 The where, what, and when of membrane protein degradation in neurons Jin, Eugene Jennifer Kiral, Ferdi Ridvan Hiesinger, Peter Robin Dev Neurobiol Review Articles Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments. Both longevity and morphological complexity represent challenges for regulated membrane protein degradation. To investigate how neurons cope with these challenges, an increasing number of recent studies investigated local, cargo‐specific protein sorting, and degradation at axon terminals and in dendritic processes. In this review, we explore the current answers to the ensuing questions of where, what, and when membrane proteins are degraded in neurons. © 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 283–297, 2018 John Wiley and Sons Inc. 2017-09-19 2018-03 /pmc/articles/PMC5816708/ /pubmed/28884504 http://dx.doi.org/10.1002/dneu.22534 Text en © 2017 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Jin, Eugene Jennifer
Kiral, Ferdi Ridvan
Hiesinger, Peter Robin
The where, what, and when of membrane protein degradation in neurons
title The where, what, and when of membrane protein degradation in neurons
title_full The where, what, and when of membrane protein degradation in neurons
title_fullStr The where, what, and when of membrane protein degradation in neurons
title_full_unstemmed The where, what, and when of membrane protein degradation in neurons
title_short The where, what, and when of membrane protein degradation in neurons
title_sort where, what, and when of membrane protein degradation in neurons
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816708/
https://www.ncbi.nlm.nih.gov/pubmed/28884504
http://dx.doi.org/10.1002/dneu.22534
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