Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer disease: a longitudinal study

BACKGROUND: Models of Alzheimer disease propose a sequence of amyloid-β (Aβ) accumulation, hypometabolism, and structural declines that precede the onset of clinical dementia. These pathological features evolve both temporally and spatially in the brain. This study aimed to characterize where in the...

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Detalles Bibliográficos
Autores principales: Gordon, Brian A., Blazey, Tyler M., Su, Yi, Hari-Raj, Amrita, Dincer, Aylin, Flores, Shaney, Christensen, Jon, McDade, Eric, Wang, Guoqiao, Xiong, Chengjie, Cairns, Nigel J., Hassenstab, Jason, Marcus, Daniel S., Fagan, Anne M., Jack, Clifford R., Hornbeck, Russ C., Paumier, Katrina L., Ances, Beau M., Berman, Sarah B., Brickman, Adam M., Cash, David M., Chhatwal, Jasmeer P., Correia, Stephen, Förster, Stefan, Fox, Nick C., Graff-Radford, Neill R., la Fougère, Christian, Levin, Johannes, Masters, Colin L., Rossor, Martin N., Salloway, Stephen, Saykin, Andrew J., Schofield, Peter R., Thompson, Paul M., Weiner, Michael M., Holtzman, David M., Raichle, Marcus E., Morris, John C., Bateman, Randall J., Benzinger, Tammie L.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816717/
https://www.ncbi.nlm.nih.gov/pubmed/29397305
http://dx.doi.org/10.1016/S1474-4422(18)30028-0

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