Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)

We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAO(R199W), associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine metabolism and causes protein aggregation, autophagy and cell death in motor neuron cell lines. These features are consistent with...

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Detalles Bibliográficos
Autores principales: Kondori, Nazanin R., Paul, Praveen, Robbins, Jacqueline P., Liu, Ke, Hildyard, John C. W., Wells, Dominic J., de Belleroche, Jacqueline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816792/
https://www.ncbi.nlm.nih.gov/pubmed/29487852
http://dx.doi.org/10.3389/fmolb.2018.00008

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