Cargando…

Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

BACKGROUND: Rictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine/threonine kinase that may play a role in cell proliferation, survival and innate or adaptive immune responses. Genetic loss of Rictor inactivates mTORC2, which directly activat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Babaev, Vladimir R., Huang, Jiansheng, Ding, Lei, Zhang, Youmin, May, James M., Linton, MacRae F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816794/ https://www.ncbi.nlm.nih.gov/pubmed/29487597 http://dx.doi.org/10.3389/fimmu.2018.00215

Ejemplares similares

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice
por: Babaev, Vladimir R., et al.
Publicado: (2014)

Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis
por: Linton, MacRae F., et al.
Publicado: (2019)

Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr(−/−) mice
por: Tao, Huan, et al.
Publicado: (2020)

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis
por: Tao, Huan, et al.
Publicado: (2015)

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
por: Erbay, Ebru, et al.
Publicado: (2009)

Scavenging dicarbonyls with 5′-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance
por: Huang, Jiansheng, et al.
Publicado: (2022)

Tanshinone IIA alleviates atherosclerosis in LDLR(−/−) mice by regulating efferocytosis of macrophages
por: Wang, Jiarou, et al.
Publicado: (2023)

T Cells in Atherosclerosis in Ldlr−/− and Apoe−/− Mice
por: Getz, Godfrey S., et al.
Publicado: (2018)

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice
por: Siuta, Michael A., et al.
Publicado: (2010)

Monocyte and macrophage immunometabolism in atherosclerosis
por: Groh, Laszlo, et al.
Publicado: (2017)

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice
por: Zhu, Lin, et al.
Publicado: (2014)

Monocytes, Macrophages, and Metabolic Disease in Atherosclerosis
por: Flynn, Michelle C., et al.
Publicado: (2019)

The Apolipoprotein-AI Mimetic Peptide L4F at a Modest Dose Does Not Attenuate Weight Gain, Inflammation, or Atherosclerosis in LDLR-Null Mice
por: Averill, Michelle M., et al.
Publicado: (2014)

Data on leukocyte PDZK1 deficiency affecting macrophage apoptosis but not monocyte recruitment, cell proliferation, macrophage abundance or ER stress in atherosclerotic plaques of LDLR deficient mice
por: Yu, Pei, et al.
Publicado: (2018)

Genetic Disruption of Myostatin Reduces the Development of Proatherogenic Dyslipidemia and Atherogenic Lesions In Ldlr Null Mice
por: Tu, Powen, et al.
Publicado: (2009)

Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice
por: Park, Kyung-Yeon, et al.
Publicado: (2016)

PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis
por: Arida, Aikaterini, et al.
Publicado: (2021)

Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr(−/−) Mice
por: Peng, Xueying, et al.
Publicado: (2022)

Innate immunity and monocyte-macrophage activation in atherosclerosis
por: Shalhoub, Joseph, et al.
Publicado: (2011)

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
por: Davis, Bryan T., et al.
Publicado: (2014)

Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr(−/−) mice
por: Rajamoorthi, Ananthi, et al.
Publicado: (2018)

Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis
por: Gomes, Diego, et al.
Publicado: (2022)

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
por: Bruen, Robyn, et al.
Publicado: (2017)

Monocyte and macrophage foam cells in diabetes-accelerated atherosclerosis
por: Cervantes, Jocelyn, et al.
Publicado: (2023)

High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3
por: Osaka, Mizuko, et al.
Publicado: (2021)

Novel RICTOR amplification harbouring entities: FISH validation of RICTOR amplification in tumour tissue after next-generation sequencing
por: Sztankovics, Dániel, et al.
Publicado: (2023)

Liraglutide Reduces Both Atherosclerosis and Kidney Inflammation in Moderately Uremic LDLr-/- Mice
por: Bisgaard, Line S., et al.
Publicado: (2016)

Debate: "How low should LDL cholesterol be lowered?" Viewpoint: "It doesn't need to be very low"
por: Fazio, Sergio, et al.
Publicado: (2001)

TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis
por: Cartland, Siân P., et al.
Publicado: (2019)

The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis
por: Moroni, Francesco, et al.
Publicado: (2019)

3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr(−/−) mice
por: Berg, Martin, et al.
Publicado: (2019)

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice
por: Riopel, Matthew, et al.
Publicado: (2018)

The role of RICTOR downstream of receptor tyrosine kinase in cancers
por: Jebali, Ahlem, et al.
Publicado: (2018)

The role of RICTOR amplification in targeted therapy and drug resistance
por: Zhao, Deze, et al.
Publicado: (2020)

Rictor maintains endothelial integrity under shear stress
por: Li, Hui, et al.
Publicado: (2022)

AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis
por: Guo, Wen, et al.
Publicado: (2013)

Biomimetic 3D Models for Investigating the Role of Monocytes and Macrophages in Atherosclerosis
por: Garcia-Sabaté, Anna, et al.
Publicado: (2020)

Innate Immune Memory in Monocytes and Macrophages: The Potential Therapeutic Strategies for Atherosclerosis
por: Guo, Zhigang, et al.
Publicado: (2022)

Glucose-Dependent Insulinotropic Polypeptide Prevents the Progression of Macrophage-Driven Atherosclerosis in Diabetic Apolipoprotein E-Null Mice
por: Nogi, Yukinori, et al.
Publicado: (2012)

Exosome Release by Glucose Deprivation Is Important for the Viability of TSC-Null Cells
por: Bae, Ji-Hyun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_idagdgcre4hlje6825umukacqc