Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

2-aminoimidazole (2-AI) compounds inhibit the formation of bacterial biofilms, disperse preformed biofilms, and re-sensitize multidrug resistant bacteria to antibiotics. 2-AIs have previously been shown to interact with bacterial response regulators, but the mechanism of interaction is still unknown...

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Detalles Bibliográficos
Autores principales: Milton, Morgan E., Minrovic, Bradley M., Harris, Danni L., Kang, Brian, Jung, David, Lewis, Caleb P., Thompson, Richele J., Melander, Roberta J., Zeng, Daina, Melander, Christian, Cavanagh, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816815/
https://www.ncbi.nlm.nih.gov/pubmed/29487854
http://dx.doi.org/10.3389/fmolb.2018.00015

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