ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance

We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay an...

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Detalles Bibliográficos
Autores principales: Yin, Hang, Wang, Lei, Liu, Hai-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816842/
https://www.ncbi.nlm.nih.gov/pubmed/29483925
http://dx.doi.org/10.1155/2018/3842198
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author Yin, Hang
Wang, Lei
Liu, Hai-Lin
author_facet Yin, Hang
Wang, Lei
Liu, Hai-Lin
author_sort Yin, Hang
collection PubMed
description We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay and amplified luminescent proximity homogeneous assay (AlphaLISA) were performed to measure CA19-9 and ENO1 concentration in plasma from PDAC patients and healthy controls. We demonstrated that ENO1 overexpression is positively correlated with clinical stage, lymph node metastasis, and poor prognosis of PDAC; ENO1 may function as a hopeful candidate diagnostic marker in combination with CA19-9 in PDAC diagnosis.
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spelling pubmed-58168422018-02-26 ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance Yin, Hang Wang, Lei Liu, Hai-Lin Gastroenterol Res Pract Research Article We investigated in this study the expression of ENO1 in tissues and plasma of PDAC patients to evaluate its clinicopathological and diagnostic significance. ENO1 protein expression was detected in tissue microarray of human PDAC and adjacent noncancer tissues. Electrochemiluminescence immunoassay and amplified luminescent proximity homogeneous assay (AlphaLISA) were performed to measure CA19-9 and ENO1 concentration in plasma from PDAC patients and healthy controls. We demonstrated that ENO1 overexpression is positively correlated with clinical stage, lymph node metastasis, and poor prognosis of PDAC; ENO1 may function as a hopeful candidate diagnostic marker in combination with CA19-9 in PDAC diagnosis. Hindawi 2018-02-01 /pmc/articles/PMC5816842/ /pubmed/29483925 http://dx.doi.org/10.1155/2018/3842198 Text en Copyright © 2018 Hang Yin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yin, Hang
Wang, Lei
Liu, Hai-Lin
ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance
title ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance
title_full ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance
title_fullStr ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance
title_full_unstemmed ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance
title_short ENO1 Overexpression in Pancreatic Cancer Patients and Its Clinical and Diagnostic Significance
title_sort eno1 overexpression in pancreatic cancer patients and its clinical and diagnostic significance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816842/
https://www.ncbi.nlm.nih.gov/pubmed/29483925
http://dx.doi.org/10.1155/2018/3842198
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