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Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response
In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816850/ https://www.ncbi.nlm.nih.gov/pubmed/29484304 http://dx.doi.org/10.1155/2018/2835761 |
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author | Zhong, Hong Ma, Minjuan Liang, Tingming Guo, Li |
author_facet | Zhong, Hong Ma, Minjuan Liang, Tingming Guo, Li |
author_sort | Zhong, Hong |
collection | PubMed |
description | In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunction are responsible for the activated immune system, including innate and adaptive responses. Of note, inflammation is the manifest accountant signal. Deeply studied microRNAs (miRNAs) have participated in many pathways involved in metabolism and immune responses to protect cells from multiple harmful stimulants, and they play an important role in determining the progress through targeting different inflammatory pathways. Thus, immune response and metabolic regulation are highly integrated with miRNAs. Collectively, miRNAs are the new targets for therapy in immune dysfunction. |
format | Online Article Text |
id | pubmed-5816850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58168502018-02-26 Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response Zhong, Hong Ma, Minjuan Liang, Tingming Guo, Li J Immunol Res Review Article In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunction are responsible for the activated immune system, including innate and adaptive responses. Of note, inflammation is the manifest accountant signal. Deeply studied microRNAs (miRNAs) have participated in many pathways involved in metabolism and immune responses to protect cells from multiple harmful stimulants, and they play an important role in determining the progress through targeting different inflammatory pathways. Thus, immune response and metabolic regulation are highly integrated with miRNAs. Collectively, miRNAs are the new targets for therapy in immune dysfunction. Hindawi 2018-02-01 /pmc/articles/PMC5816850/ /pubmed/29484304 http://dx.doi.org/10.1155/2018/2835761 Text en Copyright © 2018 Hong Zhong et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhong, Hong Ma, Minjuan Liang, Tingming Guo, Li Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response |
title | Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response |
title_full | Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response |
title_fullStr | Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response |
title_full_unstemmed | Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response |
title_short | Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response |
title_sort | role of micrornas in obesity-induced metabolic disorder and immune response |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816850/ https://www.ncbi.nlm.nih.gov/pubmed/29484304 http://dx.doi.org/10.1155/2018/2835761 |
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