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Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population

Roles of interleukin-31 (IL-31) in the development and progression of human epithelial ovarian cancer are largely unknown. Studies report that the polymorphisms, rs7977932 C>G and rs4758680 C>A in IL-31, affect the expression level of IL-31. In the present study, we examined 412 patients with...

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Autores principales: Liu, Chenlu, Wang, Yanyun, Song, Huizi, Li, Qin, Zhang, Yan, Chen, Peng, Song, Yaping, Su, Min, Huang, Qin, Wang, Mei, Zhou, Bin, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816851/
https://www.ncbi.nlm.nih.gov/pubmed/29484036
http://dx.doi.org/10.1155/2018/3503858
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author Liu, Chenlu
Wang, Yanyun
Song, Huizi
Li, Qin
Zhang, Yan
Chen, Peng
Song, Yaping
Su, Min
Huang, Qin
Wang, Mei
Zhou, Bin
Zhang, Lin
author_facet Liu, Chenlu
Wang, Yanyun
Song, Huizi
Li, Qin
Zhang, Yan
Chen, Peng
Song, Yaping
Su, Min
Huang, Qin
Wang, Mei
Zhou, Bin
Zhang, Lin
author_sort Liu, Chenlu
collection PubMed
description Roles of interleukin-31 (IL-31) in the development and progression of human epithelial ovarian cancer are largely unknown. Studies report that the polymorphisms, rs7977932 C>G and rs4758680 C>A in IL-31, affect the expression level of IL-31. In the present study, we examined 412 patients with epithelial ovarian cancer and 428 healthy individuals to explore whether these polymorphisms are associated with the epithelial ovarian cancer in Chinese women. The genotype of the polymorphisms in each individual was identified. The associations of the polymorphisms with patients' clinical characteristics and outcomes were evaluated. For rs7977932, the frequency of the CG/GG was significantly decreased in patients with epithelial ovarian cancer. However, the frequency of the rs4758680 CA/AA was significantly increased in those patients. Moreover, the frequency of rs7977932 CG/GG genotype was significantly higher in patients with less advanced FIGO stages. Kaplan-Meier curve showed that patients with CG/GG genotypes of rs7977932 had a decreased risk for recurrence compared to those with CC genotype. Our findings suggested that rs7977932 and rs4758680 of IL-31 may be associated with the development and progression of the epithelial ovarian cancer in the Chinese population. IL-31, therefore, may be a potential therapeutic target for the development of drugs to treat the disease.
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spelling pubmed-58168512018-02-26 Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population Liu, Chenlu Wang, Yanyun Song, Huizi Li, Qin Zhang, Yan Chen, Peng Song, Yaping Su, Min Huang, Qin Wang, Mei Zhou, Bin Zhang, Lin Dis Markers Research Article Roles of interleukin-31 (IL-31) in the development and progression of human epithelial ovarian cancer are largely unknown. Studies report that the polymorphisms, rs7977932 C>G and rs4758680 C>A in IL-31, affect the expression level of IL-31. In the present study, we examined 412 patients with epithelial ovarian cancer and 428 healthy individuals to explore whether these polymorphisms are associated with the epithelial ovarian cancer in Chinese women. The genotype of the polymorphisms in each individual was identified. The associations of the polymorphisms with patients' clinical characteristics and outcomes were evaluated. For rs7977932, the frequency of the CG/GG was significantly decreased in patients with epithelial ovarian cancer. However, the frequency of the rs4758680 CA/AA was significantly increased in those patients. Moreover, the frequency of rs7977932 CG/GG genotype was significantly higher in patients with less advanced FIGO stages. Kaplan-Meier curve showed that patients with CG/GG genotypes of rs7977932 had a decreased risk for recurrence compared to those with CC genotype. Our findings suggested that rs7977932 and rs4758680 of IL-31 may be associated with the development and progression of the epithelial ovarian cancer in the Chinese population. IL-31, therefore, may be a potential therapeutic target for the development of drugs to treat the disease. Hindawi 2018-02-01 /pmc/articles/PMC5816851/ /pubmed/29484036 http://dx.doi.org/10.1155/2018/3503858 Text en Copyright © 2018 Chenlu Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Chenlu
Wang, Yanyun
Song, Huizi
Li, Qin
Zhang, Yan
Chen, Peng
Song, Yaping
Su, Min
Huang, Qin
Wang, Mei
Zhou, Bin
Zhang, Lin
Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
title Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
title_full Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
title_fullStr Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
title_full_unstemmed Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
title_short Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
title_sort genetic association of interleukin-31 gene polymorphisms with epithelial ovarian cancer in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816851/
https://www.ncbi.nlm.nih.gov/pubmed/29484036
http://dx.doi.org/10.1155/2018/3503858
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