Cargando…
The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study
INTRODUCTION: The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816895/ https://www.ncbi.nlm.nih.gov/pubmed/29487870 http://dx.doi.org/10.1155/2018/6038106 |
_version_ | 1783300773578276864 |
---|---|
author | Kuciel-Lewandowska, Jadwiga Gnus, Jan Pawlik-Sobecka, Lilla Płaczkowska, Sylwia Kokot, Izabela Kasperczak, Michał Paprocka-Borowicz, Małgorzata |
author_facet | Kuciel-Lewandowska, Jadwiga Gnus, Jan Pawlik-Sobecka, Lilla Płaczkowska, Sylwia Kokot, Izabela Kasperczak, Michał Paprocka-Borowicz, Małgorzata |
author_sort | Kuciel-Lewandowska, Jadwiga |
collection | PubMed |
description | INTRODUCTION: The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particular molecules. THE AIM OF THE STUDY: The aim of this study was to assess the changes in the integrated antioxidant system under the influence of radon therapy in osteoarthritis patients. MATERIAL AND METHODS: Observation included 35 patients suffering from degenerative joints and disc disease (mean age 56.5 years) undergoing radon water therapy and control group that consisted of 15 osteoarthritis patients (mean age 54.2) without contact with radon water. Before therapy and after 18 days of treatment, serum total antioxidant status (TAS) was assessed with the use of standard colorimetric assay. RESULTS: In the study group, we observed trends to increase TAS concentration, whereas, in the control group, TAS concentration was decreasing. CONCLUSIONS: (1) Radon waters treatment influenced the level of TAS of osteoarthritis patients treated with the radon water. (2) The change in TAS concentrations in the study group may be the result of low doses of ionizing radiation, but further studies on larger patient's groups are demanded. This study is registered with number NCT03274128. |
format | Online Article Text |
id | pubmed-5816895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58168952018-02-27 The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study Kuciel-Lewandowska, Jadwiga Gnus, Jan Pawlik-Sobecka, Lilla Płaczkowska, Sylwia Kokot, Izabela Kasperczak, Michał Paprocka-Borowicz, Małgorzata Biomed Res Int Clinical Study INTRODUCTION: The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particular molecules. THE AIM OF THE STUDY: The aim of this study was to assess the changes in the integrated antioxidant system under the influence of radon therapy in osteoarthritis patients. MATERIAL AND METHODS: Observation included 35 patients suffering from degenerative joints and disc disease (mean age 56.5 years) undergoing radon water therapy and control group that consisted of 15 osteoarthritis patients (mean age 54.2) without contact with radon water. Before therapy and after 18 days of treatment, serum total antioxidant status (TAS) was assessed with the use of standard colorimetric assay. RESULTS: In the study group, we observed trends to increase TAS concentration, whereas, in the control group, TAS concentration was decreasing. CONCLUSIONS: (1) Radon waters treatment influenced the level of TAS of osteoarthritis patients treated with the radon water. (2) The change in TAS concentrations in the study group may be the result of low doses of ionizing radiation, but further studies on larger patient's groups are demanded. This study is registered with number NCT03274128. Hindawi 2018-01-02 /pmc/articles/PMC5816895/ /pubmed/29487870 http://dx.doi.org/10.1155/2018/6038106 Text en Copyright © 2018 Jadwiga Kuciel-Lewandowska et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Kuciel-Lewandowska, Jadwiga Gnus, Jan Pawlik-Sobecka, Lilla Płaczkowska, Sylwia Kokot, Izabela Kasperczak, Michał Paprocka-Borowicz, Małgorzata The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study |
title | The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study |
title_full | The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study |
title_fullStr | The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study |
title_full_unstemmed | The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study |
title_short | The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study |
title_sort | assessment of the integrated antioxidant system of the body in the course of radon therapy: a pilot study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816895/ https://www.ncbi.nlm.nih.gov/pubmed/29487870 http://dx.doi.org/10.1155/2018/6038106 |
work_keys_str_mv | AT kuciellewandowskajadwiga theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT gnusjan theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT pawliksobeckalilla theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT płaczkowskasylwia theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT kokotizabela theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT kasperczakmichał theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT paprockaborowiczmałgorzata theassessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT kuciellewandowskajadwiga assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT gnusjan assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT pawliksobeckalilla assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT płaczkowskasylwia assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT kokotizabela assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT kasperczakmichał assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy AT paprockaborowiczmałgorzata assessmentoftheintegratedantioxidantsystemofthebodyinthecourseofradontherapyapilotstudy |