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Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis
Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pH(e)) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H(+) ions reducing the intracellular pH (pH(i)). Nevertheless, how extracellular...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816902/ https://www.ncbi.nlm.nih.gov/pubmed/29487850 http://dx.doi.org/10.3389/fmed.2018.00019 |