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Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial

Background: Treatment of recurrent depressive disorders is currently only moderately successful. Increasing evidence suggests a significant relationship between adverse childhood experiences and recurrent depressive disorders, suggesting that trauma-based interventions could be useful for these pati...

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Autores principales: Ostacoli, Luca, Carletto, Sara, Cavallo, Marco, Baldomir-Gago, Paula, Di Lorenzo, Giorgio, Fernandez, Isabel, Hase, Michael, Justo-Alonso, Ania, Lehnung, Maria, Migliaretti, Giuseppe, Oliva, Francesco, Pagani, Marco, Recarey-Eiris, Susana, Torta, Riccardo, Tumani, Visal, Gonzalez-Vazquez, Ana I., Hofmann, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816922/
https://www.ncbi.nlm.nih.gov/pubmed/29487548
http://dx.doi.org/10.3389/fpsyg.2018.00074
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author Ostacoli, Luca
Carletto, Sara
Cavallo, Marco
Baldomir-Gago, Paula
Di Lorenzo, Giorgio
Fernandez, Isabel
Hase, Michael
Justo-Alonso, Ania
Lehnung, Maria
Migliaretti, Giuseppe
Oliva, Francesco
Pagani, Marco
Recarey-Eiris, Susana
Torta, Riccardo
Tumani, Visal
Gonzalez-Vazquez, Ana I.
Hofmann, Arne
author_facet Ostacoli, Luca
Carletto, Sara
Cavallo, Marco
Baldomir-Gago, Paula
Di Lorenzo, Giorgio
Fernandez, Isabel
Hase, Michael
Justo-Alonso, Ania
Lehnung, Maria
Migliaretti, Giuseppe
Oliva, Francesco
Pagani, Marco
Recarey-Eiris, Susana
Torta, Riccardo
Tumani, Visal
Gonzalez-Vazquez, Ana I.
Hofmann, Arne
author_sort Ostacoli, Luca
collection PubMed
description Background: Treatment of recurrent depressive disorders is currently only moderately successful. Increasing evidence suggests a significant relationship between adverse childhood experiences and recurrent depressive disorders, suggesting that trauma-based interventions could be useful for these patients. Objectives: To investigate the efficacy of Eye Movement Desensitization and Reprocessing therapy (EMDR) in addition to antidepressant medication (ADM) in treating recurrent depression. Design: A non-inferiority, single-blind, randomized clinical controlled trial comparing EMDR or CBT as adjunctive treatments to ADM. Randomization was carried out by a central computer system. Allocation was carried out by a study coordinator in each center. Setting: Two psychiatric services, one in Italy and one in Spain. Participants: Eighty-two patients were randomized with a 1:1 ratio to the EMDR group (n = 40) or CBT group (n = 42). Sixty-six patients, 31 in the EMDR group and 35 in the CBT group, were included in the completers analysis. Intervention: 15 ± 3 individual sessions of EMDR or CBT, both in addition to ADM. Participants were followed up at 6-months. Main outcome measure: Rate of depressive symptoms remission in both groups, as measured by a BDI-II score <13. Results: Sixty-six patients were analyzed as completers (31 EMDR vs. 35 CBT). No significant difference between the two groups was found either at the end of the interventions (71% EMDR vs. 48.7% CBT) or at the 6-month follow-up (54.8% EMDR vs. 42.9% CBT). A RM-ANOVA on BDI-II scores showed similar reductions over time in both groups [F(6,59) = 22.501, p < 0.001] and a significant interaction effect between time and group [F(6,59) = 3.357, p = 0.006], with lower BDI-II scores in the EMDR group at T1 [mean difference = –7.309 (95% CI [–12.811, –1.806]), p = 0.010]. The RM-ANOVA on secondary outcome measures showed similar improvement over time in both groups [F(14,51) = 8.202, p < 0.001], with no significant differences between groups [F(614,51) = 0.642, p = 0.817]. Conclusion: Although these results can be considered preliminary only, this study suggests that EMDR could be a viable and effective treatment for reducing depressive symptoms and improving the quality of life of patients with recurrent depression. Trial registration: ISRCTN09958202.
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spelling pubmed-58169222018-02-27 Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial Ostacoli, Luca Carletto, Sara Cavallo, Marco Baldomir-Gago, Paula Di Lorenzo, Giorgio Fernandez, Isabel Hase, Michael Justo-Alonso, Ania Lehnung, Maria Migliaretti, Giuseppe Oliva, Francesco Pagani, Marco Recarey-Eiris, Susana Torta, Riccardo Tumani, Visal Gonzalez-Vazquez, Ana I. Hofmann, Arne Front Psychol Psychology Background: Treatment of recurrent depressive disorders is currently only moderately successful. Increasing evidence suggests a significant relationship between adverse childhood experiences and recurrent depressive disorders, suggesting that trauma-based interventions could be useful for these patients. Objectives: To investigate the efficacy of Eye Movement Desensitization and Reprocessing therapy (EMDR) in addition to antidepressant medication (ADM) in treating recurrent depression. Design: A non-inferiority, single-blind, randomized clinical controlled trial comparing EMDR or CBT as adjunctive treatments to ADM. Randomization was carried out by a central computer system. Allocation was carried out by a study coordinator in each center. Setting: Two psychiatric services, one in Italy and one in Spain. Participants: Eighty-two patients were randomized with a 1:1 ratio to the EMDR group (n = 40) or CBT group (n = 42). Sixty-six patients, 31 in the EMDR group and 35 in the CBT group, were included in the completers analysis. Intervention: 15 ± 3 individual sessions of EMDR or CBT, both in addition to ADM. Participants were followed up at 6-months. Main outcome measure: Rate of depressive symptoms remission in both groups, as measured by a BDI-II score <13. Results: Sixty-six patients were analyzed as completers (31 EMDR vs. 35 CBT). No significant difference between the two groups was found either at the end of the interventions (71% EMDR vs. 48.7% CBT) or at the 6-month follow-up (54.8% EMDR vs. 42.9% CBT). A RM-ANOVA on BDI-II scores showed similar reductions over time in both groups [F(6,59) = 22.501, p < 0.001] and a significant interaction effect between time and group [F(6,59) = 3.357, p = 0.006], with lower BDI-II scores in the EMDR group at T1 [mean difference = –7.309 (95% CI [–12.811, –1.806]), p = 0.010]. The RM-ANOVA on secondary outcome measures showed similar improvement over time in both groups [F(14,51) = 8.202, p < 0.001], with no significant differences between groups [F(614,51) = 0.642, p = 0.817]. Conclusion: Although these results can be considered preliminary only, this study suggests that EMDR could be a viable and effective treatment for reducing depressive symptoms and improving the quality of life of patients with recurrent depression. Trial registration: ISRCTN09958202. Frontiers Media S.A. 2018-02-13 /pmc/articles/PMC5816922/ /pubmed/29487548 http://dx.doi.org/10.3389/fpsyg.2018.00074 Text en Copyright © 2018 Ostacoli, Carletto, Cavallo, Baldomir-Gago, Di Lorenzo, Fernandez, Hase, Justo-Alonso, Lehnung, Migliaretti, Oliva, Pagani, Recarey-Eiris, Torta, Tumani, Gonzalez-Vazquez and Hofmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Ostacoli, Luca
Carletto, Sara
Cavallo, Marco
Baldomir-Gago, Paula
Di Lorenzo, Giorgio
Fernandez, Isabel
Hase, Michael
Justo-Alonso, Ania
Lehnung, Maria
Migliaretti, Giuseppe
Oliva, Francesco
Pagani, Marco
Recarey-Eiris, Susana
Torta, Riccardo
Tumani, Visal
Gonzalez-Vazquez, Ana I.
Hofmann, Arne
Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial
title Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial
title_full Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial
title_fullStr Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial
title_full_unstemmed Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial
title_short Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial
title_sort comparison of eye movement desensitization reprocessing and cognitive behavioral therapy as adjunctive treatments for recurrent depression: the european depression emdr network (eden) randomized controlled trial
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816922/
https://www.ncbi.nlm.nih.gov/pubmed/29487548
http://dx.doi.org/10.3389/fpsyg.2018.00074
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