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Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme

Identifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equival...

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Autores principales: Rasmussen, Kirsten, Rauscher, Hubert, Mech, Agnieszka, Riego Sintes, Juan, Gilliland, Douglas, González, Mar, Kearns, Peter, Moss, Kenneth, Visser, Maaike, Groenewold, Monique, Bleeker, Eric A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817049/
https://www.ncbi.nlm.nih.gov/pubmed/29074277
http://dx.doi.org/10.1016/j.yrtph.2017.10.019
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author Rasmussen, Kirsten
Rauscher, Hubert
Mech, Agnieszka
Riego Sintes, Juan
Gilliland, Douglas
González, Mar
Kearns, Peter
Moss, Kenneth
Visser, Maaike
Groenewold, Monique
Bleeker, Eric A.J.
author_facet Rasmussen, Kirsten
Rauscher, Hubert
Mech, Agnieszka
Riego Sintes, Juan
Gilliland, Douglas
González, Mar
Kearns, Peter
Moss, Kenneth
Visser, Maaike
Groenewold, Monique
Bleeker, Eric A.J.
author_sort Rasmussen, Kirsten
collection PubMed
description Identifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physico-chemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted.
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spelling pubmed-58170492018-02-22 Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme Rasmussen, Kirsten Rauscher, Hubert Mech, Agnieszka Riego Sintes, Juan Gilliland, Douglas González, Mar Kearns, Peter Moss, Kenneth Visser, Maaike Groenewold, Monique Bleeker, Eric A.J. Regul Toxicol Pharmacol Article Identifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physico-chemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted. Elsevier 2018-02 /pmc/articles/PMC5817049/ /pubmed/29074277 http://dx.doi.org/10.1016/j.yrtph.2017.10.019 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rasmussen, Kirsten
Rauscher, Hubert
Mech, Agnieszka
Riego Sintes, Juan
Gilliland, Douglas
González, Mar
Kearns, Peter
Moss, Kenneth
Visser, Maaike
Groenewold, Monique
Bleeker, Eric A.J.
Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
title Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
title_full Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
title_fullStr Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
title_full_unstemmed Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
title_short Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
title_sort physico-chemical properties of manufactured nanomaterials - characterisation and relevant methods. an outlook based on the oecd testing programme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817049/
https://www.ncbi.nlm.nih.gov/pubmed/29074277
http://dx.doi.org/10.1016/j.yrtph.2017.10.019
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