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Pneumococcal neuraminidase activates TGF-β signalling

Neuraminidase A (NanA) is an important virulence factor that is anchored to the pneumococcal cell wall and cleaves sialic acid on host substrates. We noted that a secreted allele of NanA was over-represented in invasive pneumococcal isolates and promoted the development of meningitis when swapped in...

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Detalles Bibliográficos
Autores principales:	Gratz, Nina, Loh, Lip Nam, Mann, Beth, Gao, Geli, Carter, Robert, Rosch, Jason, Tuomanen, Elaine I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817201/ https://www.ncbi.nlm.nih.gov/pubmed/28749326 http://dx.doi.org/10.1099/mic.0.000511

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