Synthesis of Trifluoroacetyl‐Substituted Cyclopropanes Using Onium Ylides

The use of carbonyl‐stabilized ammonium‐ and sulfonium ylides allows for the synthesis of highly‐functionalized trifluoroacetyl‐substituted cyclopropanes. It turned out that the diastereoselectivities strongly depend on the nature of the chosen ylide and the employed base. The products could be obta...

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Detalles Bibliográficos
Autores principales: Winter, Michael, Gaunersdorfer, Christina, Roiser, Lukas, Zielke, Katharina, Monkowius, Uwe, Waser, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817241/
https://www.ncbi.nlm.nih.gov/pubmed/29491744
http://dx.doi.org/10.1002/ejoc.201701699
Descripción
Sumario:The use of carbonyl‐stabilized ammonium‐ and sulfonium ylides allows for the synthesis of highly‐functionalized trifluoroacetyl‐substituted cyclopropanes. It turned out that the diastereoselectivities strongly depend on the nature of the chosen ylide and the employed base. The products could be obtained in good yields under operationally simple conditions.

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