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A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817256/ https://www.ncbi.nlm.nih.gov/pubmed/29491837 http://dx.doi.org/10.3389/fphar.2018.00104 |
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author | Chen, Shao-Ru Dai, Yan Zhao, Jing Lin, Ligen Wang, Yitao Wang, Ying |
author_facet | Chen, Shao-Ru Dai, Yan Zhao, Jing Lin, Ligen Wang, Yitao Wang, Ying |
author_sort | Chen, Shao-Ru |
collection | PubMed |
description | Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol. We systemically discuss the structure-activity-relationship of triptolide, celastrol, and their derivatives. Furthermore, we propose the use of structural derivatives, targeted therapy, and combination treatment as possible solutions to reduce toxicity and increase therapeutic window of these potent natural products from T. wilfordii Hook F. |
format | Online Article Text |
id | pubmed-5817256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58172562018-02-28 A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F Chen, Shao-Ru Dai, Yan Zhao, Jing Lin, Ligen Wang, Yitao Wang, Ying Front Pharmacol Pharmacology Triptolide and celastrol are predominantly active natural products isolated from the medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar pharmacological activities, including anti-cancer, anti-inflammation, anti-obesity, and anti-diabetic activities. Triptolide and celastrol also provide neuroprotection and prevent cardiovascular and metabolic diseases. However, toxicity restricts the further development of triptolide and celastrol. In this review, we comprehensively review therapeutic targets and mechanisms of action, and translational study of triptolide and celastrol. We systemically discuss the structure-activity-relationship of triptolide, celastrol, and their derivatives. Furthermore, we propose the use of structural derivatives, targeted therapy, and combination treatment as possible solutions to reduce toxicity and increase therapeutic window of these potent natural products from T. wilfordii Hook F. Frontiers Media S.A. 2018-02-14 /pmc/articles/PMC5817256/ /pubmed/29491837 http://dx.doi.org/10.3389/fphar.2018.00104 Text en Copyright © 2018 Chen, Dai, Zhao, Lin, Wang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Chen, Shao-Ru Dai, Yan Zhao, Jing Lin, Ligen Wang, Yitao Wang, Ying A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F |
title | A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F |
title_full | A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F |
title_fullStr | A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F |
title_full_unstemmed | A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F |
title_short | A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F |
title_sort | mechanistic overview of triptolide and celastrol, natural products from tripterygium wilfordii hook f |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817256/ https://www.ncbi.nlm.nih.gov/pubmed/29491837 http://dx.doi.org/10.3389/fphar.2018.00104 |
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