Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b

Multiple epigenetic mechanisms, including histone acetylation and nucleosome remodeling, are known to be involved in long-term memory formation. Enhancing histone acetylation by deleting histone deacetylases, like HDAC3, typically enhances long-term memory formation. In contrast, disrupting nucleoso...

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Autores principales: Shu, Guanhua, Kramár, Enikö A., López, Alberto J., Huynh, Grace, Wood, Marcelo A., Kwapis, Janine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817283/
https://www.ncbi.nlm.nih.gov/pubmed/29449454
http://dx.doi.org/10.1101/lm.046920.117
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author Shu, Guanhua
Kramár, Enikö A.
López, Alberto J.
Huynh, Grace
Wood, Marcelo A.
Kwapis, Janine L.
author_facet Shu, Guanhua
Kramár, Enikö A.
López, Alberto J.
Huynh, Grace
Wood, Marcelo A.
Kwapis, Janine L.
author_sort Shu, Guanhua
collection PubMed
description Multiple epigenetic mechanisms, including histone acetylation and nucleosome remodeling, are known to be involved in long-term memory formation. Enhancing histone acetylation by deleting histone deacetylases, like HDAC3, typically enhances long-term memory formation. In contrast, disrupting nucleosome remodeling by blocking the neuron-specific chromatin remodeling subunit BAF53b impairs long-term memory. Here, we show that deleting HDAC3 can ameliorate the impairments in both long-term memory and synaptic plasticity caused by BAF53b mutation. This suggests a dynamic interplay exists between histone acetylation/deacetylation and nucleosome remodeling mechanisms in the regulation of memory formation.
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spelling pubmed-58172832019-03-01 Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b Shu, Guanhua Kramár, Enikö A. López, Alberto J. Huynh, Grace Wood, Marcelo A. Kwapis, Janine L. Learn Mem Brief Communication Multiple epigenetic mechanisms, including histone acetylation and nucleosome remodeling, are known to be involved in long-term memory formation. Enhancing histone acetylation by deleting histone deacetylases, like HDAC3, typically enhances long-term memory formation. In contrast, disrupting nucleosome remodeling by blocking the neuron-specific chromatin remodeling subunit BAF53b impairs long-term memory. Here, we show that deleting HDAC3 can ameliorate the impairments in both long-term memory and synaptic plasticity caused by BAF53b mutation. This suggests a dynamic interplay exists between histone acetylation/deacetylation and nucleosome remodeling mechanisms in the regulation of memory formation. Cold Spring Harbor Laboratory Press 2018-03 /pmc/articles/PMC5817283/ /pubmed/29449454 http://dx.doi.org/10.1101/lm.046920.117 Text en © 2018 Shu et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Shu, Guanhua
Kramár, Enikö A.
López, Alberto J.
Huynh, Grace
Wood, Marcelo A.
Kwapis, Janine L.
Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b
title Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b
title_full Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b
title_fullStr Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b
title_full_unstemmed Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b
title_short Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b
title_sort deleting hdac3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit baf53b
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817283/
https://www.ncbi.nlm.nih.gov/pubmed/29449454
http://dx.doi.org/10.1101/lm.046920.117
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