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Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen

PURPOSE: To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). METH...

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Autores principales: Miere, Alexandra, Oubraham, Hassiba, Amoroso, Francesca, Butori, Pauline, Astroz, Polina, Semoun, Oudy, Bruyere, Elsa, Pedinielli, Alexandre, Addou-Regnard, Manar, Jung, Camille, Cohen, Salomon Y., Souied, Eric H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817334/
https://www.ncbi.nlm.nih.gov/pubmed/29507810
http://dx.doi.org/10.1155/2018/3751702
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author Miere, Alexandra
Oubraham, Hassiba
Amoroso, Francesca
Butori, Pauline
Astroz, Polina
Semoun, Oudy
Bruyere, Elsa
Pedinielli, Alexandre
Addou-Regnard, Manar
Jung, Camille
Cohen, Salomon Y.
Souied, Eric H.
author_facet Miere, Alexandra
Oubraham, Hassiba
Amoroso, Francesca
Butori, Pauline
Astroz, Polina
Semoun, Oudy
Bruyere, Elsa
Pedinielli, Alexandre
Addou-Regnard, Manar
Jung, Camille
Cohen, Salomon Y.
Souied, Eric H.
author_sort Miere, Alexandra
collection PubMed
description PURPOSE: To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). METHODS: Consecutive patients with neovascular AMD underwent multimodal imaging, including OCTA (AngioPlex, CIRRUS HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, OH) at baseline and at three monthly follow-up visits. Treatment-naive AMD patients undergoing anti-VEGF loading phase were included in group A, while treated patients were included in group B. Qualitative and quantitative OCTA analyses were performed on outer retina to choriocapillaris (ORCC) slab. CNV size was measured using a free image analysis software (ImageJ, open-source imaging processing software, 2.0.0). RESULTS: Twenty-five eyes of 25 patients were enrolled in our study (mean age 78.32 ± 6.8 years): 13 treatment-naïve eyes in group A and 12 treated eyes in group B. While qualitative analysis revealed no significant differences from baseline to follow-up in the two groups, quantitative analysis showed in group A a significant decrease in lesion area (P = 0.023); in group B, no significant change in the lesion area was observed during anti-VEGF therapy (P = 0.93). CONCLUSION: Treatment-naïve and treated eyes with CNV secondary to neovascular AMD respond differently to anti-VEGF therapy. This should be taken into account when using OCTA for CNV follow-up or planning therapeutic strategies.
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spelling pubmed-58173342018-03-05 Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen Miere, Alexandra Oubraham, Hassiba Amoroso, Francesca Butori, Pauline Astroz, Polina Semoun, Oudy Bruyere, Elsa Pedinielli, Alexandre Addou-Regnard, Manar Jung, Camille Cohen, Salomon Y. Souied, Eric H. J Ophthalmol Research Article PURPOSE: To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). METHODS: Consecutive patients with neovascular AMD underwent multimodal imaging, including OCTA (AngioPlex, CIRRUS HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, OH) at baseline and at three monthly follow-up visits. Treatment-naive AMD patients undergoing anti-VEGF loading phase were included in group A, while treated patients were included in group B. Qualitative and quantitative OCTA analyses were performed on outer retina to choriocapillaris (ORCC) slab. CNV size was measured using a free image analysis software (ImageJ, open-source imaging processing software, 2.0.0). RESULTS: Twenty-five eyes of 25 patients were enrolled in our study (mean age 78.32 ± 6.8 years): 13 treatment-naïve eyes in group A and 12 treated eyes in group B. While qualitative analysis revealed no significant differences from baseline to follow-up in the two groups, quantitative analysis showed in group A a significant decrease in lesion area (P = 0.023); in group B, no significant change in the lesion area was observed during anti-VEGF therapy (P = 0.93). CONCLUSION: Treatment-naïve and treated eyes with CNV secondary to neovascular AMD respond differently to anti-VEGF therapy. This should be taken into account when using OCTA for CNV follow-up or planning therapeutic strategies. Hindawi 2018-02-04 /pmc/articles/PMC5817334/ /pubmed/29507810 http://dx.doi.org/10.1155/2018/3751702 Text en Copyright © 2018 Alexandra Miere et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Miere, Alexandra
Oubraham, Hassiba
Amoroso, Francesca
Butori, Pauline
Astroz, Polina
Semoun, Oudy
Bruyere, Elsa
Pedinielli, Alexandre
Addou-Regnard, Manar
Jung, Camille
Cohen, Salomon Y.
Souied, Eric H.
Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen
title Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen
title_full Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen
title_fullStr Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen
title_full_unstemmed Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen
title_short Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen
title_sort optical coherence tomography angiography to distinguish changes of choroidal neovascularization after anti-vegf therapy: monthly loading dose versus pro re nata regimen
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817334/
https://www.ncbi.nlm.nih.gov/pubmed/29507810
http://dx.doi.org/10.1155/2018/3751702
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